Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Will Russia have a tuberculosis vaccine?

Specialists of the State Research Center for Virology and Biotechnology “Vector” have tested on mice a new experimental preparation for tuberculosis vaccinal prevention (it cannot be called a vaccine yet, as it has not received all required verifications and approvals). The preparation is nontoxic and does not provoke the animals’ immune response.

Tuberculosis that takes away lives of two million people remains a very dangerous disease. Physicians all over the world are working to produce efficient tuberculosis vaccines, but their effort has not succeeded yet. All preparations available do not ensure complete protection from the disease.

For example, efficiency of one of the most widespread vaccines – BCG – varies from 80% to 0%. The experimental vaccine, the Novosibirsk researchers are working at, is a DNA fragment that codes the ESAT-6 mycobacterial antigen. Production of such a vaccine became possible after thorough investigation of genomes of mycobacteria – causative agent of tuberculosis – and of a congener bacterium - Mycobacterium bovis.

The majority of existing tuberculosis vaccines represent weakened mycobacteria cultures: a vaccine is supposed to provoke the immune response, but not the disease. The bacteria are weakened by removing from them the genes that are responsible for virulent properties, including the gene that codes the ESAT-6. It is absent from all existing Mycobacterium bovis BCG vaccine cultures. The Novosibirsk researchers staked specifically on this protein, which should not pose danger by itself .

Having established a proper genetically engineered construction, the researchers surrounded it by a polysacharide covering of polyglucin and spermidine. The covering reliably protects the DNA from enzymes that can destroy it. In the organism, polyglucin gradually decomposes, and the DNA becomes accessible to the immune system cells. The mice were immunized by the obtained preparation for three times. The preparation was injected intramuscularly at a two-week interval. The reference group animals were immunized by polysaccharides and the DNA, which did not contain the vaccine gene.

After vaccination, the mice were observed for 10 more days, and during this period, they did not lose weight and did not show any other symptoms of health impairment. Nevertheless, the animals had to be slaughtered to investigate their immune system reaction. Vaccines should stimulate cell-mediated immunity, and indeed, lymphocyte clones were formed with mice after immunization. The lymphocyte clones started to divide actively in response to introduction of the real ESAT-6 protein, at that the reaction significantly exceeded the background reaction. As for the reference group mice, their lymphocytes did not react to the protein injection. The analysis has proved that specific cell-mediated immunity was formed with vaccinated mice.

This is not a vaccine yet, it is only the first step to its development. As a matter of fact, the step has been successful.

Olga Myznikova | alfa
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>