Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New research from the University of Bristol aims to eliminate Streptococcus infections

06.03.2008
Professor Howard Jenkinson in the Department of Oral & Dental Science (Dental School) at the University of Bristol has been awarded a grant of £285,000 from The Wellcome Trust to research ways to combat diseases caused by Streptococcus bacteria.

Familiar to those who suffer from ‘strep’ throat, Streptococcus are the most common bacteria in the human mouth and throat. They are linked to a number of health problems, some mild, some life-threatening, ranging from tooth and gum disease to meningitis, pneumonia, endocarditis (inflammation of the inner layer of the heart) and necrotizing fasciitis (‘flesh-eating disease’).

Streptococcus are potent bacteria which are becoming increasingly resistant to treatment by antibiotics. The rate of severe invasive Streptococcus infections is about 60 per 100,000.

The bacteria cause disease in the body by first attaching to tissues. By looking at how this happens, Professor Jenkinson and his team will be able to develop new ways to block the bacteria. One goal is to reduce the rates at which disease-causing Streptococcus are transferred between humans.

This could be achieved by developing user-friendly vaccines or natural biological products, which can be taken by mouth, to eliminate the harmful bacteria. This approach lessens antibiotic usage and would significantly decrease infection rates in those most susceptible e.g. children, expectant mothers and the elderly.

Professor Jenkinson says, ‘Streptococcus bacteria are amongst the most commonly encountered in infections, and for the most part we depend totally on antibiotics to fight them. Our research will help develop new infection-control methods that do not rely on conventional antibiotics, and will also help identify people who are at higher risk of infections.’

The research will look at the interactions between a protein called AgI/II, which is found on the surface of Streptococcus bacteria, and a protein called gp340, which is found on teeth, in saliva and in airways.

The team will measure how ‘sticky’ the Streptococcus bacteria proteins are as they attach to gp340 on tissue surfaces. By pinpointing the sticky parts of the protein, the team will be able to identify which are responsible for streptococci invading and attacking the body. The research will look at how to block this process and thus develop new ways to prevent bacterial infection.

The study involves Drs Michele Barbour, Linda Franklin and Sarah Maddocks, also from the Department of Oral & Dental Science; Dr Aras Kadioglu, University of Leicester and Dr Nicklas Strömberg, Umeå University. The first results are due to be presented internationally in June 2008.

Dara O'Hare | alfa
Further information:
http://www.bristol.ac.uk
http://www.bris.ac.uk/news/2008/12017945171.html

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>