Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

LGC licenses Orchid to test for drug metabolising gene

10.06.2002


LGC, the UK`s leading independent provider of genetic testing services, has issued its first testing licence for the key DNA variant in the drug metabolising gene CYP2D6 to Orchid BioSciences Inc. LGC holds the exclusive commercialisation rights to the patented diagnosis of this `poor metaboliser` gene variation and, in granting this first licence, will make access to this beneficial technology available to leading companies internationally for the first time.



The gene CYP2D6 controls an enzyme in the human liver. About 6% of the Caucasian population have a genetically pre-determined deficiency in this enzyme. This means that they do not metabolise about 20% of currently prescribed medications correctly. The genetic variation in the gene CYP2D6, known as *4, was first invented by Imperial Cancer Research Fund (ICRF) scientists and patented by the Fund in the early 1990s. One of the inventors, Professor Roland Wolf, joined the University of Dundee and ICRF granted the University an exclusive licence. Subsequently, the University granted exclusive rights to LGC to commercialise and sub-license the technology in September 2001.

Dr Paul Debenham, Director of Life Sciences at LGC, and who has found himself to have the poor metaboliser gene status, said: "There is tremendous excitement in the field of genetically pre-determined drug metabolism, known as pharmacogenetics, about the growing understanding of how each individual may differ in their ability to respond to various medications, and in particular to avoid serious adverse reactions. This is an exciting start to the expansion of the opportunity for the public at large to benefit from understanding their own capability to respond to prescribed medications."


The first sub-licensee, Orchid BioSciences Inc, has taken a non-exclusive licence for North America for an undisclosed sum, and the gene diagnostic will be an essential element in their Orchid GeneShield business focused on pharmacogenomics and personalised medicine. Product offerings being developed by the Orchid GeneShield business are designed to enable physicians, patients and health care providers to better match the right drug to the right patient. LGC is also in discussions with other companies to respond to their interests in licensing and developing tests built around the *4 genetic test.

Dr Richard Worswick, LGC`s Chief Executive, said: "We foresee this as the first of many licensing deals and the forerunner of tremendous growth in the pharmacogenetics business sector. We are most pleased to have completed this non-exclusive agreement with Orchid BioSciences for North America."

Imelda Topping | alfa
Further information:
http://www.lgc.co.uk/news_story.asp?strareano=47_2&intelement=4234

More articles from Health and Medicine:

nachricht A 'half-hearted' solution to one-sided heart failure
24.11.2017 | Boston Children's Hospital

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New proton record: Researchers measure magnetic moment with greatest possible precision

High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons

The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

IceCube experiment finds Earth can block high-energy particles from nuclear reactions

24.11.2017 | Physics and Astronomy

A 'half-hearted' solution to one-sided heart failure

24.11.2017 | Health and Medicine

Heidelberg Researchers Study Unique Underwater Stalactites

24.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>