Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nanomedicine system engineered to enhance therapeutic effects of injectable drugs

04.03.2008
In an article featured on the cover of the March issue of “Nature Nanotechnology,” Mauro Ferrari, Ph.D., of The University of Texas Health Science Center at Houston presented a proof-of-concept study on a new multistage delivery system (MDS) for imaging and therapeutic applications.

This discovery could go a long way toward making injectable drugs more effective. The study is included in the March 2 Advance Online Publication on “Nature Nanotechnology’s” Web site (http://www.nature.com/nnano/index.html)

“This is next generation nanomedicine,” said Ferrari, the senior author. “Now, we’re engineering sophisticated nanostructures to elude the body’s natural defenses, locate tumors and other diseased cells, and release a payload of therapeutics, contrasting agents, or both over a controlled period. It’s the difference between riding a bicycle and a motorcycle.”

The study - “Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications” - was conducted with researchers from The University of Texas M. D. Anderson Cancer Center and Rice University.

Nanotechnology offers new and powerful tools to design and to engineer novel drug delivery systems and to predict how they will work once inside the body. “The field of therapeutic nanoparticles began with tiny drug-encapsulated fat bubbles called liposomes, now commonly used in cancer clinics worldwide. Targeting molecules were later added to liposomes and other nanovectors to assist in directing them to diseased cells,” Ferrari said.

Getting intravenous agents to their intended targets is no easy task. It’s estimated that approximately one of every 100,000 molecules of agent reaches its desired destination. Physicians are faced with the quandary of increasing the dosage, which can lead to side effects or reducing the dosage, which can limit the therapeutic benefits.

The multistage approach, according to Ferrari, is needed to circumvent the body’s natural defenses or biobarriers, which act as obstacles to foreign objects injected in the blood stream. “To overcome this problem, we hypothesized and developed a multifunctional MDS comprising stage 1 mesoporous particles loaded with one or more types of stage 2 nanoparticles, which can in turn carry either active agents or higher-stage particles. We have demonstrated the loading, controlled release and simultaneous in vitro delivery of quantum-dots and carbon nanotubes to human vascular cells,” the authors write.

In addition to circumventing biobarriers, Ferrari’s team is working on the biochemical modifications required to efficiently deliver the MDS to a specific cancer lesion. “We have preliminary data that show that we can localize a payload of diagnostic agents, therapeutic agents or combination of both to target cells. Once on site, the molecules can be released in a controlled way and then the MDS will degrade in 24 to 48 hours, be transformed into orthosilicic acid and leave no trace in the body,” Ferrari said.

Lead author Ennio Tasciotti, Ph.D., senior postdoctoral fellow in the NanoMedicine Research Center at the UT Health Science Center at Houston, said the proof-of-concept study would have not been possible without a multidisciplinary effort including contributions from mathematicians, physicists, engineers, chemists and biologists.

“We are dealing with objects that are in the billionth of a meter size range and to study such objects we used cutting edge technologies,” Tasciotti said. “The characterization of the particles was performed using scanning electron and atomic force microscopy, dynamic light scattering, fluorimetry and flow cytometry. The interaction of particles with cells was studied using fluorescence and confocal microscopy as well as a series of assays intended to determine cell viability and internalization rate of the nanoparticles.”

Robert Cahill | EurekAlert!
Further information:
http://www.uth.tmc.edu

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>