Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hebrew University student developing drug to treat epilepsy, migraines, chronic pain

07.06.2002


Ph.D. candidate Nina Isoherranen wins Kaye Awards



Nina Isoherranen, a Ph.D. candidate at the Hebrew University School of Pharmacy, was awarded a Kaye Innovation Award this week for developing a new medication to treat epilepsy, migraine headaches, and chronic pain that does not cause birth defects in animal models, unlike other medicines currently used to treat epilepsy.

Ms. Isoherranen explained that 1% of the population suffers from epilepsy, a central nervous system (CNS) disorder that can cause violent seizures. As a result, people suffering from epilepsy take medication throughout their entire life to prevent seizures. Though several medicines have been developed to treat epilepsy, they are not effective on more than 30% of epilepsy patients and cause side effects.


David H. Eisenberg Professor of Pharmacy Meir Bialer, who is supervising Ms. Isoherranen’s work together with Pharmaceutical Chemistry Prof. Boris Yagen, said that they hope to sign a contract with a pharmaceutical company that will allow them to begin clinical trials on the new medication in the next few years. So far the medication has been successfully tested on laboratory animals.

Ms. Isoherranen, Prof. Bialer, and Prof. Yagen, whose areas of expertise include developing antiepileptic and CNS drugs, spent the past four years working on developing an antiepileptic drug that would be more effective and not cause the side effects common to existing antiepileptic drugs.

Ms. Isoherranen explained that valproic acid is one of the most common medicines used to treat epilepsy and is also popular for treating migraine headaches, chronic pain, and manic depression. However, if a woman takes valproic acid while she is pregnant, it increases the chance of a birth defect by 2.5. It also can cause liver problems and weight gain.

Ms. Isoherranen combined valproic acid with taurine, a substance found in the brain that helps to control epilepsy. The end product is more potent than valproic acid and apparently lacks the major side effects, she said.

At 27, Ms. Isoherranen is the youngest of this year’s Kaye Prize recipients. She immigrated to Israel four years ago, after completing a masters degree in analytical chemistry at the University of Helsinki, Finland.



The Kaye Innovation Awards at the Hebrew University have been awarded annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the University to develop innovative methods and inventions with good commercial potential which will benefit the University and society.

Pictures available upon request. For further information, contact:
Heidi Gleit, HU foreign press liaison: tel. 972-2-588-2904; cell, 972-64-454-593; email heidig@savion.cc.huji.ac.il
Orit Sulitzeanu, HU spokeswoman: tel. 972-2-588-2811


Heidi J. Gleit | EurekAlert

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>