Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Mimicking a human disease in mice: a new model for the Parkinson related illness multiple system atrophy


In this month`s issue of EMBO Reports Kahle et al. describe how they genetically engineered a mouse to show pathological symptoms similar to those of human patients suffering from the neural disease Multiple System Atrophy (MSA), also known as Shy-Drager-Syndrome. The model could help researchers to develop and test new efficient drugs against this wide spread disease.

More than 100,000 Europeans and 100,000 US-Americans suffer from MSA. Affected individuals either show symptoms similar to those of patients suffering from Parkinson`s Disease or have a strong deterioration in their sense of balance. For this reason the disease is often diagnosed incorrectly. Doctors know very little about the pathology of the disease. However, one characteristic is that some brain cells show abnormal changes. Affected mature oligodendrocytes, the cells that form the isolating outer layer surrounding nerve fibers, produce a small protein called alpha-synuclein. They deposit this protein in the form of pathological structures called glial cytoplasmic inclusions.

Healthy mature oligodendrocytes do not produce this protein at all.
Kahle and colleagues "implanted" the human gene for the alpha-synuclein

protein into the mouse genome. As a result, the researchers found insoluble inclusion bodies of alpha-synuclein in the mouse`s oligodendrocytes. "In patients, the affected cells die as the individual ages. This is something we could not yet observe in our mice," says Philipp Kahle, a researcher at the Ludwig Maximilian University, Munich, Germany. "But we are confident that in a next step we can produce mice that will also show this symptom. This will help us to understand more about the disease and can help researchers to develop and test drugs against multiple system atrophy."

Ellen Peerenboom | alfa
Further information:

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>