Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New Genetic Association with Schizophrenia Found by Researchers

Schizophrenia emerges from an altered pattern of brain development, and researchers continue to search for the genes that cause the brain to develop along a path that ultimately leads to schizophrenia. In a high priority article to be published in Biological Psychiatry on March 1st, researchers report their findings on a new genetic link to schizophrenia.

A prior genetic mapping study indicated that a particular gene, multiple epidermal growth factor-like domains 10 or MEGF10, may be associated with schizophrenia. In this new paper, Chen and colleagues directly studied this particular MEGF10 gene in both schizophrenia patients and healthy control subjects.

They found that a variant of the MEGF10 gene is associated with the heritable risk for schizophrenia in family-based and case-control genetic studies. Further, the MEGF10 gene appears to be expressed to a greater extent in post-mortem brain tissue from individuals diagnosed with schizophrenia compared to tissue from a group of unaffected individuals.

Dr. Xiangning Chen, corresponding author for this article and assistant professor of psychiatry and human genetics in the Virginia Commonwealth University School of Medicine, explains that “the significance of the paper is that it provides evidence that a gene, i.e. MEGF10, directly involved in apoptosis is found associated with schizophrenia. It has long been speculated that dysfunction of apoptosis may be a cause of schizophrenia, but there [has been] little direct evidence.” Apoptosis is an important biological process of programmed cell death in humans and other complex organisms, and abnormal apoptotic processes have been implicated in a variety of diseases.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments on the curiosity of the association between schizophrenia and the MEGF10 gene, which influences the development of skin cells (the epidermis): “One clue may be that nerve cells and skin cells are derived from the same type of primitive cells early in the development of the embryo. Another link may be that features of epidermal development, such as the development of fingerprints, are abnormal in schizophrenia.“

The findings of this study indicate that it may be important for the field of schizophrenia research to more intensively study MEGF10, to understand how it influences brain development, and how it might be related to the treatment of schizophrenia.

Jayne Dawkins | alfa
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>