Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Receptor revealed that turns on genes after consuming unsaturated fats

28.02.2008
In a paper published in the scientific journal PlosONE scientists from Wageningen University in the Netherlands demonstrate the tremendous importance of dietary fat as a regulator of gene expression. Via a combination of several nutrigenomic tools Linda Sanderson and her colleagues reveal that dietary unsaturated fatty acids govern a huge number of genes and do so almost entirely via a special receptor called PPARa.

PPARa, which stands for Peroxisome Proliferator Activated Receptor alpha, is a receptor that can be found in numerous tissues, including liver, heart and intestine. It reacts to certain drugs by turning on specific genes, yet can also respond to fatty acids and fatty acid look-a-likes. Activation of PPARa is known to lower levels of triglycerides in blood, providing a rationale for their use in patients suffering from altered blood lipid levels.

In their nutrigenomics study, the research team led by Linda Sanderson fed mice individual fatty acids in the form of synthetic triglycerides. Using a technique called microarray, which allows for monitoring the expression of thousands of genes simultaneously, they were able to determine exactly which genes are turned on in the mouse liver and which ones are turned off. The researchers found that the fatty acid DHA has the most significant impact and changes the expression of around 600 genes. DHA is found in fatty fish and fish oil and has been associated with numerous health benefits, including lowering of plasma triglycerides and decreasing blood clotting.

The most remarkable about the study is that the effects of unsaturated fatty acids are almost entirely lost in mice that lack the PPARa receptor.From the literature it is known that numerous receptors can supposedly bind fatty acids and turn on genes. Most of these receptors belong to the family of the so called 'nuclear hormone receptors', which includes receptors that bind steroid hormones and fat soluble vitamins. However, it was unknown how important they are in an actual living animal. The new data show that PPARa is by far the most important.

Many of the genes that are turned on by unsaturated fatty acids are involved in breaking down fatty acids to generate energy. This mechanism likely protects the liver cell from build-up of unsaturated fatty acids, which is harmful to the cell. It also likely accounts for the lowering of plasma triglycerides by fish oil.

Until now, all nutritional interventions with dietary fat in either mice or human subjects involved a mixture of fatty acids. For that reason, it has been very difficult to draw clear conclusions about the effects of individual fatty acids. The mixed nutritional/pharmacological intervention with synthetic triglycerides pursued by Sanderson and colleagues represents a creative and novel way to study the molecular effects of dietary fat. They expect that their approach will set a new standard for many future nutrigenomic studies.

Jac Niessen | alfa
Further information:
http://www.wur.nl
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001681
http://www.nutrigenomicsconsortium.nl/index.html

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>