“Our findings will help doctors better predict who will respond best to temozolomide, which has recently been proposed as a new treatment for gliomatosis cerebri,” said Marc Sanson, MD, PhD, with INSERM, the French government health agency, in Paris, France. “Before now, we weren’t sure which factors influenced how well a person with this type of brain tumor would respond to the treatment.”
For the study, 25 people with gliomatosis cerebri underwent genetic testing and received monthly treatments of temozolomide for up to two years.
The study found nearly all of the participants who were missing chromosome 1p and 19q had a higher response rate to temozolomide and lived longer.
“Eighty-eight percent of those people with this genetic signature responded well to temozolomide compared to only 25 percent of those people without the genetic abnormality,” said Sanson. “In addition, those without 1p and 19q survived an average five and half years compared to only 15 months for the group with intact 1p and 19q.
Those missing 1p and 19q also had more months without the tumor further progressing. Therefore, temozolomide is now our first choice of treatment for patients with gliomatosis cerebri, especially when missing chromosomes 1p and 19q.”
Angela Babb | EurekAlert!
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29.03.2017 | Technische Universität München
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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