Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein loss in urine predicts effectiveness of hypertension medication

08.02.2008
People with albuminuria, increased protein loss in the urine, have an increased risk of kidney and cardiovascular diseases.

Cornelis Boersma, pharmacist and PhD student at the University of Groningen, has analysed the medical data of over 8,500 Groningers and discovered that preventive measures work better if the amount of protein loss is higher. This has important consequences for future prevention programmes. The results of this research were published on 30 January 2008 in the British Journal of Clinical Pharmacology.

The kidneys filter urea from the blood. This occurs in the millions of capillaries (very thin blood vessels) which make up a kidney. If the filtering does not work properly, protein is released into the urine – an indication that the capillaries are not functioning properly. At the same time, this can be a sign that the rest of the blood vessels in the body are not functioning properly either.

PREVEND study
The PREVEND study was set up in order to investigate whether people with protein loss in the urine have an increased risk of kidney and cardiovascular diseases (PREVEND = Prevention of REnal and Vascular ENd-stage Disease). To this end, over 8,500 Groningers submitted urine in 1997 and the protein levels in these samples were carefully measured in the laboratory. The Groningers were then tracked for years, particularly concerning their medicine use and the occurrence of cardiovascular disease.
ACE inhibitor
A recent analysis of the Groningen data by Cornelis Boersma has revealed that people with high blood pressure only have an increased risk of cardiovascular disease if they also have protein loss in the urine. What is more important is the discovery that the effectiveness of antihypertensives depends on the level of protein loss in the urine: the greater the protein loss, the more effective the hypertension medications are against cardiovascular disease. A GP has to treat 111 people with hypertension in order to prevent 1 instance of stroke or heart attack if there is no protein loss, but only 8 if there is protein loss. In addition, these new data suggest that – if you want to prevent cardiovascular disease – the best medication for people with more protein loss is perhaps a so-called ACE inhibitor (a specific antihypertensive).
Screening
These results will have important consequences for any large-scale prevention programme: by screening for albuminuria, people with hypertension, and thus a greater risk of cardiovascular disease, can be more quickly identified. In addition, it is now possible to determine which people can best be prescribed antihypertensives. In such a prevention programme, for example, people's urine could be tested in a laboratory once every four years and when anomalous values are discovered medication can be prescribed. The researchers now want to investigate which would be the most beneficial and cost-effective screening programme for which groups of people.

Communication Office | alfa
Further information:
http://www.prevend.org/Userfiles/109Boersma.pdf
http://www.rug.nl/Corporate/nieuws/archief/archief2008/persberichten/015_08

More articles from Health and Medicine:

nachricht Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>