Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Targeting gut bugs could revolutionise future drugs

01.02.2008
Revolutionary new ways to tackle certain diseases could be provided by creating drugs which change the bugs in people's guts, according to a Perspective article published today in the journal Nature Reviews Drug Discovery.

Trillions of bugs known as gut microbes live symbiotically in the human gut. They play a key role in many of the processes that take place inside the body. Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity.

The authors of the Perspective argue that targeting gut microbes with new drug therapies, rather than concentrating on the mechanisms in the human body which are the current focus of most drug development programmes, could provide an array of uncharted possibilities for fighting disease. Much research is still needed to untangle the precise role played by each different type of bug.

Professor Jeremy Nicholson, one of the authors of the Perspective from the Department of Biomolecular Medicine at Imperial College London, explained: "It's only recently that we've discovered the huge influence that bugs in the gut have on people's health. The exciting thing about this is that it should be easier to create drugs that can change the bugs than it is to re-engineer human cells and signalling pathways inside the body. Also, if we're not interfering with the body's pathways, these drugs should have less toxic side-effects."

Research has already shown that the makeup of an individual's gut microbes is affected by their diet and other environmental factors. A recent study led by scientists from Imperial College showed that it is possible to alter the makeup of bugs in a mouse's gut, affecting their metabolism, using probiotics.

"We already know that external factors such as altering your diet can change the makeup of the bugs in your gut, so these kinds of therapies will mean a more holistic approach to medicine, looking not just at pharmaceutical treatments but also at lifestyle and nutrition. I think that in ten years' time it will be normal for scientists to take gut bugs into consideration when they are creating new medicines," added Professor Nicholson.

Laura Gallagher | alfa
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Touch Displays WAY-AX and WAY-DX by WayCon

27.06.2017 | Power and Electrical Engineering

Drones that drive

27.06.2017 | Information Technology

Ultra-compact phase modulators based on graphene plasmons

27.06.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>