Metabolic syndrome is a group of cardiovascular risk factors, including obesity, hypertension, prediabetes, and reduced HDL (“good”) cholesterol. Because it is difficult to know when a child is at risk for metabolic syndrome, some doctors fear that children may not be properly diagnosed as a result. The February 2008 issue of The Journal of Pediatrics focuses on this issue by publishing a series of articles in an attempt to work toward a cohesive definition of metabolic syndrome in children.
Five articles of the series were completed by researchers from the Pediatric Metabolic Syndrome Working Group (PMSWG), a team of researchers from various institutions across the United States. The members of the PMSWG explored the potential for a unified and cohesive definition for metabolic syndrome. The researchers evaluated how current definitions relate to the number of children diagnosed with metabolic syndrome. They found that because of the variety of definitions used by pediatricians, it is difficult to estimate the prevalence of the syndrome among children and adolescents. Additionally, the researchers looked at how well each metabolic risk factor predicts future health issues. According to Dr. Terry Huang, “these papers represent summaries of the current state of knowledge for factors related to metabolic syndrome.” By gathering this information, the PMSWG hopes to provide a frame of reference for pediatricians working with metabolic syndrome.
Dr. John Morrison and colleagues from Cincinnati Children’s Medical Center, Cincinnati Jewish Hospital, and Maryland Medical Research Institute collected data from a 25-30 year study concerning cardiovascular risk factors. They found that metabolic syndrome in children may have a direct link to type 2 diabetes in adulthood.
In a related article, Dr. Claudio Maffeis and colleagues from The Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology used body mass index (BMI), waist circumference, and weight to height ratios to determine obesity in a group of 974 children. They found that evaluating waist circumference and weight to height ratio measurements may be more accurate in determining metabolic risk than using body mass index alone.
These articles demonstrate that symptoms of adult metabolic syndrome begin in childhood and may be directly related to obesity. They also illustrate the need for a clear definition of metabolic syndrome in children. According to Dr. Reginald Washington, “once this definition exists, medical providers who care for children will know what to look for in order to identify children who are at risk to develop adult metabolic syndrome.” Such a definition could lead to better treatment of childhood metabolic syndrome, which could positively impact the growing obesity epidemic.These studies are reported in the following:
•“Metabolic Syndrome Rates in United States Adolescents, from the National Health and Nutrition Examination Survey, 1999-2002” by Stephen Cook, MD, Peggy Auinger, MS, Chaoyang Li, MD, PhD, and Earl S. Ford, MD, MPH
•“Examining Metabolic Syndrome Definitions in Overweight Hispanic Youth: A Focus on Insulin Resistance” by Gabriel Q. Shaibi, PhD, PT, and Michael I. Goran, PhD
•“Comparison of Different Definitions of Pediatric Metabolic Syndrome: Relation to Abdominal Adiposity, Insulin Resistance, Adiponectin, and Inflammatory Biomarkers” by SoJung Lee, PhD, Fida Bacha, MD, Neslihan Gungor, MD, and Silva Arslanian, MD
•“Defining the Metabolic Syndrome in Children and Adolescents: Will the Real Definition Please Stand Up?” by Earl S. Ford, MD, MPH, and Chaoyang Li, MD, PhD
•“Sensitivity, Specificity, and Predictive Values of Pediatric Metabolic Syndrome Components in Relation to Adult Metabolic Syndrome: The Princeton LRC Follow-up Study” by Terry T-K Huang, PhD, MPH, Tonya R. Nansel, PhD, Allen R. Belsheim, MA, and John A. Morrison, PhD
•“Childhood Obesity Predicts Adult Metabolic Syndrome: The Fels Longitudinal Study” by Shumei S. Sun, PhD, Ruohong Liang, MS, Terry T-K Huang, PhD, MPH, Stephen R. Daniels, MD, PhD, Silva Arslanian, MD, Kiang Liu, PhD, Gilman D. Grave, MD, and Roger M. Siervogel, PhD
•“Metabolic Syndrome in Childhood Predicts Adult Metabolic Syndrome and Type 2 Diabetes Mellitus 25 to 30 Years Later” by John A. Morrison, PhD, Lisa Aronson Friedman, ScM, Ping Wang, PhD, and Charles J. Glueck, MD
•“Waist-to-Height Ratio, a Useful Index to Identify High Metabolic Risk in Overweight Children” by Claudio Maffeis, MD, Claudia Banzato, MD, and Giorgio Talamini, MD, on behalf of The Obesity Study Group of The Italian Society of Pediatric Endocrinology and Diabetology.
The articles appear in The Journal of Pediatrics, Volume 152 Number 2 (February 2008), published by Elsevier.
Brigid Huey | alfa
Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin
One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
26.06.2017 | Life Sciences
26.06.2017 | Physics and Astronomy
26.06.2017 | Information Technology