The only solution in the absence of real human models is to create computerised "in-silico" models that simulate the real heart and enable possible drugs and therapies to be tested without risk to people. Although this is still some way off becoming a reality, substantial progress has been made, and the next steps were plotted at a major workshop held recently by the European Science Foundation (ESF).
The workshop highlighted how recent progress in imaging technologies was helping heart modellers overcome the big dilemma they have faced up till now - actually proving that the models really are an accurate representation of the real human heart. This has been the big "catch 22" of heart modelling, that in order to create a realistic model, you need accurate and extensive data from real hearts for calibration.
"Validation of the models is very important, and was raised at the workshop," said Blanca Rodriguez, scientific coordinator of the ESF workshop, and senior cardiac researcher at Oxford University, Europe's leading centre for cardiac modelling. "One of the problems has been that it is much easier to get experimental data from animals than humans."
Such animal data can help calibrate some aspects of the models, but only data from human hearts can fine tune them to the point at which they can actually make useful predictions and test therapies. Fortunately such data is now becoming available as a result of dramatic progress in imaging techniques that can observe cardiac activity externally without need for invasive probes. "We are now getting data at very high resolutions, and that allows us to model things in more detail, with greatly improved anatomy and structure," said Rodriguez. This in turn requires access to greater computational power and more sophisticated software, both of which are available at Oxford.
The models in turn are allowing researchers to study disease and understand what can go wrong, which is the first step towards developing cures. One of the most important diseases being modelled is myocardial ischaemia, which is the loss of blood supply to part of the heart muscle, leading ultimately to failure and potentially death if untreated.
Typically victims of heart failure never fully recover their former health and vigour, because part of the heart muscle has been permanently lost. However stem cell therapy holds the promise of being able to regenerate heart muscle destroyed by disease, but this will require careful testing to eliminate possibly dangerous side effects, such as cancer and disruption of normal heart rhythms, leading to arrhythmia, or irregular heart beats. Here again the heart models could play a vital role. "They could be used to model stem cells' behaviour, and see how they are incorporated into the heart," said Rodriguez.
The ESF workshop also had another dimension - to kick start a Europe-wide effort to catch up with the US in this vital field. Oxford was once the world leader, for remarkably the first cardiac model was developed almost half a century ago in 1961 by Dennis Noble, who although now officially retired is still assisting Rodriguez and colleagues today. Noble's original model was of just of a single heart cell. But since the late 1990s, the models have been extended to the whole organ, incorporating multiple cell types.
The workshop identified three key issues that had to be addressed, according to Rodriguez. The first one was to improve the links within Europe's scattered heart modelling community. The second two recommendations, less specific to Europe, were to create a standard and robust software infrastructure for sharing heart models and associated data, and to define exactly how to calibrate the models more effectively from experimental data.
The next step is to act on these recommendations, but Rodriguez is now confident that Europe is well placed to regain its early momentum in this vital field of medical research.
The ESF Exploratory Workshop on European Heart Modelling and Supporting Technology was held in Oxford, United Kingdom, in May 2007. The Exploratory Workshop titled Exploring Symbolic Value Creation In Organizations was held on 6-9 September 2007 in Milano, Italy. Each year, ESF supports approximately 50 Exploratory Workshops across all scientific domains. These small, interactive group sessions are aimed at opening up new directions in research to explore new fields with a potential impact on developments in science.
Thomas Lau | alfa
Nanoparticles as a Solution against Antibiotic Resistance?
15.12.2017 | Friedrich-Schiller-Universität Jena
Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences