Having the neighboring cell just split into two identical daughter cells would seem to be the simplest way to keep bodies from falling apart.
However that would be a recipe for uncontrolled growth, said John W. Pepper of The University of Arizona in Tucson.
"If there were only one cell type in the group, it would act like an evolving population of cells. Individual cells would get better and better at surviving and reproducing," said Pepper, a UA assistant professor of ecology and evolutionary biology and a member of UA's BIO5 Institute.
"When cells reach the point where they divide constantly, instead of only when needed, they are cancer cells."
Instead, multicellular organisms use a seemingly inefficient process to replace lost cells, Pepper said. An organ such as the skin calls upon skin-specific stem cells to produce intermediate cells that in turn produce skin cells.Although great at their job, the new skin cells are evolutionary dead ends.
What was in it for the single cells?"Probably they got to be part of something more powerful," Pepper said.
The National Institutes of Health, the Pennsylvania Department of Health, the Pew Charitable Trust and the Santa Fe Institute funded the research.
Pepper became curious about the origins of cooperation between cells while he was a postdoctoral fellow at the Santa Fe Institute in New Mexico.
"Organisms are just a bunch of cells," he said.
"If you understand the conditions under which they cooperate, you can understand the conditions under which cooperation breaks down. Cancer is a breakdown of cooperation."
Pepper and his colleagues used a kind of computer model called an agent-based model to compare different modes of cellular reproduction.
The results indicate that if cells reproduce by simply making carbon-copies of themselves, the cells' descendants are more likely to accumulate mutations.In contrast, if cellular reproduction was much more complicated, the cells'
Mari N. Jensen | The University of Arizona
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