According to the study published this month in Epilepsia, early treatment of epilepsy-prone rats with the anti-convulsant medication ethosuximide before the onset of seizures led to a marked suppression of seizures both later in life and months after treatment stopped.
“Current treatments for epilepsy may control seizures, but they do nothing to alter the underlying disease,” said Hal Blumenfeld, M.D., associate professor of neurology and lead author of the study. “These findings are important because they set the stage for prevention of epilepsy in genetically susceptible people.”
Epilepsy is a common neurological disorder that affects about 50 million people worldwide. It is characterized by seizures—temporary loss of consciousness or muscular control—that are precipitated by abnormal electrical overload on neurons within the brain.
Using a combination of molecular profiling, electroencephalogram (EEG) recordings, and power spectral analysis, Blumenfeld and his colleagues demonstrated that ethosuximide effectively blocked the expression of an epilepsy-associated maladaptive protein within neurons of the brain and reduced the number of seizures in treated animals.
“These findings prove that prevention of epilepsy in people is an achievable goal,” Blumenfeld said. “Strategies for primary prevention of diseases like epilepsy will be increasingly important as genetic prediction of these diseases improves.”
He said the results must be confirmed in other animals and with other medications before moving on to human treatment trials.
Jacqueline Weaver | EurekAlert!
TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute
Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences