Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Recognizing blood poisoning quickly

01.12.2011
Speed can save lives – especially in the case of blood poisoning. The more quickly and directly doctors recognize and treat sepsis, the greater the patient’s chances of survival. With the help of a new biochip, physicians will now be able to analyze blood within their own practice.

Is the patient suffering from blood poisoning? To answer this question, the doctor draws a blood sample and sends it to a central laboratory for testing. This takes up valuable time, which could cost the patient his life. In future, physicians will be able to analyze blood there and then and have the results within twenty minutes.


The biochip is analyzed in a fully automatic portable device. Physicians find out right away if the patient suffers from blood poisoning. © Fraunhofer IPM

This is made possible by a biochip, developed by scientists at the Fraunhofer Institute for Physical Measurement Techniques IPM in Freiburg. “To analyze the biochip we have also designed a fully automatic device to carry out all the examination steps,” explains Dr. Albrecht Brandenburg, group manager at the IPM. “All the doctor has to do is place the sample in the apparatus and wait for the results.”

Meanwhile, within the device there’s plenty going on: it starts by preparing the blood sample. Red blood cells are separated from the blood and the plasma that remains is guided onto the biochip. When patients are suffering from sepsis, their immune system reacts by producing certain proteins. The biochip uses these in its diagnosis: there are antibodies positioned on the chip which fit these proteins like a key fits a lock. If the proteins are present in the blood, the antibodies fish them out of the fluid and bind them to the chip. But how does the apparatus know if proteins have been caught? “The chip is rinsed with a solution containing the appropriate antibodies, which have in turn been marked with a fluorescent dye,” explains IPM scientist Dr. Manuel Kemmler. “These bind to the proteins – meaning antibodies, protein and marked antibodies are all firmly linked to each other and to the chip’s surface. When the chip is illuminated, the dye lights up.” The apparatus sees lots of little illuminated dots that show the protein was in the blood. If the patient is healthy, however, the chip remains dark.

The researchers can even test for different proteins at the same time in one cycle. This is done by placing various different catcher molecules on the chip, to which specific molecules in the blood attach themselves. A cunning selection of proven protein markers allows the scientists to obtain additional important information about the severity and cause of the illness.

Together with colleagues from a university hospital, the researchers have already successfully tested prototypes of the device and biochip. Each biochip can only be used once – so they have to be affordable. “We predict that in the long run, with production on a large enough scale, each chip will cost no more than one euro,” says Brandenburg. There are various possible applications: other conditions such as heart attacks or cancers can also be investigated this way. What’s more, the chip facilitates doping and urine testing as well as the quality assessment of foodstuffs.

Dr. Albrecht Brandenburg | Fraunhofer Research News
Further information:
http://www.fraunhofer.de/en/press/research-news/2011/december/recognizing-blood-poisoning-quickly.html

Further reports about: Biochip Sepsis blood cell blood poisoning blood sample red blood cells

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>