Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Radiation a risk factor for brain tumors in young people

05.11.2014

In people under age 30, radiation is a risk factor for a type of brain tumor called a meningioma, a Loyola University Medical Center study has found.

Researchers analyzed records of 35 patients who were diagnosed with meningiomas before age 30. Five had been exposed to ionizing radiation earlier in their lives.

They include two patients who received radiation for leukemia at ages 5 and 6; one who received radiation at age 3 for a brain tumor known as a medulloblastoma; and one who received radiation for an earlier skull base tumor that appeared to be a meningioma.

The fifth patient had been exposed at age 9 to radiation from the Chernobyl nuclear power plant disaster in Ukraine. Twenty years later, he was diagnosed with a meningioma.

In the five patients, the average latency period for the tumors was 23.5 years.

The study was published in the online journal Neuroscience Discovery.

"The results of this preliminary study have prompted us to look closely at radiation's effects on the brain," said Loyola neurosurgeon Vikram Prabhu, MD, first author of the study. Dr. Prabhu specializes in treating brain tumors.

A meningioma is a tumor, usually benign, that arises from the meninges — the membranes that surround the brain and spinal cord. Meningiomas comprise about one-third of all primary brain tumors, but are rare in children and young adults. It is one of the commonest brain tumors treated at Loyola by Dr. Prabhu and his team.

They are doing a follow-up study on patients of all ages who have been treated at Loyola for meningiomas. In collaboration with Dr. Omer Iqbal, from the Department of Pathology, they are analyzing the genetics and biology of tumor samples to find how they differ from samples of tumors not linked to radiation.

Loyola oncologist Kevin Barton, MD, a co-author of the study, said: "It is important to compare and contrast these post-radiation meningiomas with de novo meningiomas, both clinically and biologically, in order to further define optimal therapy."

Researchers so far have identified 14 meningioma patients who were exposed to radiation earlier in their lives. They include three patients who were exposed to Chernobyl radiation and 11 patients who received therapeutic radiation for such conditions as leukemia, medulloblastoma tumors and fungal infections of the scalp.

Dr. Edward Melian, a radiation oncologist at Loyola and co-author of the study, said patients generally have done very well with radiation treatments. "Although we have identified radiation as a risk factor for meningiomas, radiation remains an important part of the treatment regimen for certain lesions, and is helping us obtain good results for our patients."

Dr. Prabhu said physicians have become more judicious in using radiation for therapeutic purposes. For example, radiation no longer is used to treat fungal scalp infections.

"We have become more aware of the tumor-inducing properties of radiation," Dr. Prabhu said.

People who have been exposed to large doses of radiation to the head face a small risk of later developing brain tumors. If such a person experiences symptoms associated with brain tumors, including headaches, seizures, vomiting and blurry vision, he or she should see a doctor, Dr. Prabhu said.

Dr. Prabhu is a professor in the Department of Neurological Surgery at Loyola University Chicago Stritch School of Medicine. Dr. Melian is an associate professor in the departments of Radiation Oncology and Neurological Surgery. Dr. Barton is an associate professor in the Division of Hematology/Oncology. Other co-authors are Loyola biostatistician Rong Guo, PhD; Douglas Anderson, MD, a professor in the Department of Neurological Surgery; and Edward Perry, MD, who completed a residency in neurological surgery at Loyola.

The study is titled "Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology and the recurrence rate."

Jim Ritter | EurekAlert!
Further information:
http://loyolamedicine.org/

Further reports about: Loyola Radiation diagnosed fungal leukemia meningioma risk factor tumors

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>