In the west, this means saving money and reducing stress on health-care systems. In developing countries, this means saving lives. The method has been jointly developed by researchers at Chalmers and the Sahlgrenska Academy, University of Gothenburg, Sweden.
Every year hundreds of thousands of children in developing countries suffer from winter vomiting disease or related viral infections. The disease also hits the western world's health care services hard, closing departments and delaying treatments.
All viral infections are caused by an individual virus binding to specific receptors on the surface of a host cell. The thousands of copies of the virus which the host cell produces, quickly attack new cells and illness becomes inevitable. Early identification and understanding of how a virus binds to the cell's surface is vital in overcoming the disease.
Researchers at Chalmers and at the University of Gothenburg's Sahlgrenska Academy have now taken an important step towards both making diagnosis more effective and improving options for developing virus-inhibiting drugs. The results, soon to be published in the prestigious journal Physical Review Letters, are based on a method developed at Chalmers.
“Briefly, the method makes it possible to identify and study individual viruses, 40 nanometres in size. No other method, based on similar simple analysis, provides the same level of sensitivity without the virus having been modified in some way before the analysis,” says Professor Fredrik Höök who led the study.
At the Sahlgrenska Academy, Professor Göran Larson has succeeded in identifying a number of sugar molecules which bind strongly to the particular virus that causes winter vomiting disease. This knowledge has now been combined with the methodology developed at Chalmers and the result is an opportunity to study in detail the very first contact between a virus and the surface of the cell which contains a number of different sugar molecules.
The increased level of sensitivity offered by this method may make it central to the assessment of drug candidates developed with the aim of preventing the virus from binding to its host cell.
By looking at the weak bindings which are the precursor to the strong interaction which causes the virus to be taken up by the cell, the researchers will also be able to study how the virus mutates year on year. These mutations are one of the causes of increased intensity of outbreaks, making quick diagnosis of new viral strains of vital importance.
Furthermore, as the individual virus can be identified, the researchers hope that it will be possible to attack the very small quantities of virus responsible for spreading the disease, e.g. via drinking water, at an earlier stage than is possible today.
The research is supported by Vinnova, the Swedish Foundation for Strategic Research and Chalmers’ Area of Advance Nanoscience and Nanotechnology.For more information, please contact: Professor Göran Larson
Helena Aaberg | idw
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Life Sciences
27.04.2017 | Physics and Astronomy
27.04.2017 | Earth Sciences