Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Quicker detection and treatment of severe sepsis

23.05.2011
Sepsis is the name of an infection that causes a series of reactions in the body, which in the worst case can prove fatal.

The problem for both patients and doctors is that the early symptoms are difficult to distinguish from less dangerous infections such as a severe flu or winter vomiting disease. A researcher at Lund University in Sweden has now discovered a substance in the blood which shows both whether a patient has sepsis and how serious the case is.

“Approximately one in five patients with sepsis who are admitted to hospital are at risk of developing severe sepsis within the first 24 hours. If the doctor doesn’t immediately understand that the patient is seriously ill, the risk is that he or she does not receive adequate treatment. The patient could also end up on a ward with lower staffing levels and thus less close supervision”, says doctor and researcher Adam Linder.

In sepsis (formerly called blood poisoning), the immune system overreacts to an infection, which triggers a series of events in the body. Among other things, the blood vessels begin to leak, resulting in a fall in blood pressure that eventually damages the kidneys, heart and brain. Sepsis is the tenth most common cause of death in the world, and the most common cause of death among already weak patients in hospital intensive care units.

Sepsis is treated with antibiotics, fluids and oxygen. But first, the patients must be diagnosed with sepsis, yet the markers used do not always give a correct diagnosis. Adam Linder has found a better biomarker in protein HBP (heparin-binding protein). This is released by a certain type of white blood cell in amounts which correspond to the immune system’s reaction: the greater the overreaction – and thus the risk of sepsis – the greater the amount of HBP in the blood of a patient.

Measurements of HBP can also be used in connection with meningitis. There are two forms of the disease, bacterial meningitis and viral meningitis. Again, it is important to get a quick and accurate diagnosis in order to reduce the risk of complications and death. The amount of HBP in a patient’s spinal fluid has been shown to provide a more accurate diagnosis than the methods currently used.

However, for HBP measurements to be used successfully in hospitals it must be possible to perform the analysis quickly.

“I analysed my samples in the lab, which took six hours. A doctor in an accident and emergency department cannot wait that long. The time must be reduced to no more than one hour”, says Adam Linder.

Hansa Medical, a company in Lund, is currently developing patented methods to quickly analyse HBP in connection with both meningitis and sepsis.

Adam Linder presented his thesis on HBP on 13 May. The title of the thesis is Studies on heparin binding protein in bacterial infections.

Adam Linder can be contacted by telephone, +46 46 17 13 09 or +46 709 280233, or by email, adam.linder@med.lu.se.

Ingela Björck | idw
Further information:
http://www.lu.se.

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>