Using data from the electronic health records of over two and half million people researchers have developed, validated and evaluated the new lifetime 'score' which takes account, among many other factors, social deprivation and ethnicity. The results of their research is published today (9 Dec 2010) in the BMJ.
Julia Hippisley-Cox, Professor of Clinical Epidemiology and General Practice in the School of Community Health, said: "This new score has the potential to identify younger people who have a high risk over the course of their lifetime, who are currently not picked up by the more conventional '10 year' risk scores. By identifying people at a younger age, GPs will have more chance of intervening before heart disease sets in, to help reduce their lifetime risk through treatments and lifestyle advice."
Heart disease is the leading cause of premature death in the UK and a major cause of disability. The majority of GPs in the UK currently have access to the QRISK2 formula which predicts cardiovascular disease risk over 10 years. It was developed using data from over 500 GP practices, feeding into the QRESEARCH® database, run by the University in collaboration with EMIS.
Until now there have been no published risk scores that estimate the lifetime risk of heart disease, while incorporating social deprivation or ethnicity. The new lifetime score also takes account of other factors including: smoking status, systolic blood pressure, cholesterol levels, body mass index, family history of heart disease, and age and sex.
The new lifetime 'score' shows that different people could be at high risk compared with the 10 year risk score. The new 'score' will identify people for possible intervention at a much younger age. The risk calculator is available at www.qrisk.org/lifetime
Using the QRESEARCH® database Professor Hippisley-Cox, together with experts from Queen Mary's School of Medicine and Dentistry in London and the Avon Primary Care Research Collaborative in Bristol, have been able to produce a model based on a large, ethnically diverse population. The information could be updated to take account of improvements in data quality and refined over time to reflect trends in population characteristics, changes in clinical requirements and improved methods for communicating cardiovascular risk to patients.
Professor Hippisley-Cox said: "Our study leaves a number of unanswered questions. These include whether early intervention in people with a high lifetime risk but low 10-year risk would have a greater clinical benefit than later intervention; whether people at low absolute risk would value long term treatments with little short term gain; determining the appropriate threshold for lifetime risk to balance the expected benefits against the potential adverse effects of interventions such as statins. Although more research is needed to closely examine the cost effectiveness and acceptability of such an approach, this does represent an important advance in the field of cardiovascular disease prevention".
Cardiovascular disease includes coronary heart disease (angina and myocardial infarction), stroke, or transient ischaemic attacks. National policies now support targeting of interventions to reduce the risk of cardiovascular disease among high risk patients.
The University of Nottingham has a broad research portfolio but has also identified and badged 13 research priority groups, in which a concentration of expertise, collaboration and resources create significant critical mass. Key research areas at Nottingham include energy, drug discovery, global food security, biomedical imaging, advanced manufacturing, integrating global society, operations in a digital world, and science, technology & society.
Through these groups, Nottingham researchers will continue to make a major impact on global challenges.
Lindsay Brooke | EurekAlert!
23.03.2017 | Technische Universität München
How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Life Sciences
23.03.2017 | Power and Electrical Engineering
23.03.2017 | Earth Sciences