What are the substances contained in olives that protect against memory loss? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University (TU) of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project “NeurOliv” is funded by the German Federal Ministry of Education and Research.
It has long been proven that people who follow a Mediterranean diet and keep physically and mentally active are less likely to suffer from dementia. Olives in particular appear to play a key role in this regard.
Members of the BMBF project “NeurOliv” gather for the project’s kick-off meeting. First row, left to right: Dr. Jens Zotzel (N-ZYME), Alexander Webersinke (N-ZYME), Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Jascha Folk (TU Darmstadt). Second row, left to right: Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Prof. Warzecha (TU Darmstadt), Dr. Gunter Eckert (GU).
But just what are the substances contained in these small, oval fruit that are so valuable? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University (TU) of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project “NeurOliv” has a project volume of 1.3 million Euros and is funded by the Federal Ministry of Education and Research as part of the high-tech initiative "KMU-innovativ Biochance".
This collaboration combines a number of approaches, the initiative of which came from N-Zyme BioTec GmbH. The aim is to use substances contained in olives to develop new functional food for the ageing society, which will protect against Alzheimer’s disease.
“We want to test whether olive polyphenols can even help to cure the disease. This is why we believe our products also relate to the pharmaceutical sector”, says Dr. Joachim Tretzel, Managing Director of N-Zyme BioTec GmbH. The high-tech initiative of the German government was set up to fund small and medium-sized enterprises.
The team, led by Prof. Heribert Warzecha of the Department of Biology of TU Darmstadt, is examining the development of new biotechnological processes designed to extract specific plant substances. With the relevant genetic information, bacterial cultures are said to help bring out substances in a pure and defined form.
“Our new techniques make it easier to extract substances from olive leaves and significantly improve low yields“, explains Warzecha. “When it comes to production, this means we aren’t dependent on the seasonal harvesting of olives in growing areas”, adds Dr. Stefan Marx, also Managing Director of N-Zyme BioTec.
The “nutritional-neuroscience” working group of Dr. Gunter Eckert, food chemist and private lecturer at the Goethe University Frankfurt (GU), will test the effectiveness of these biotechnologically produced olive substances. Firstly, olive substances will be tested in cell culture models, which may protect against Alzheimer’s disease. “We focus on changes to the power houses of nerve cells (mitochondria), which change early on in Alzheimer’s disease”, says Eckert. The most active compounds should then demonstrate in a mouse model of the disease that they can improve brain function.
“We are testing the hypothesis that certain polyphenols from olives slow down disease processes in the brain, improve mitochondrial dysfunction and, as a result, provide evidence to suggest they protect against Alzheimer’s disease”, explains pharmacological expert Eckert, summarizing the objective of his research. GU researchers have been awarded funding of 288,000 Euros for the project. In another research project, Eckert is examining the relationship between diet and exercise with regard to the development of Alzheimer’s disease.
Dr. Gunter Eckert, Goethe University, Tel. +49 (0)69 798-29378, E-Mail email@example.com; Dr. Stefan Marx, N-Zyme BioTec GmbH Tel. +49 (0)6151 3912-772, E-Mail: firstname.lastname@example.org; Prof. Dr. Heribert Warzecha, TU Darmstadt, Tel. +49 (0)6151) 16-20900, E-Mail: email@example.com
Download images from: www.uni-frankfurt.de/54645204
Picture 1 (standing in front of the building): Members of the BMBF project “NeurOliv” gather for the project’s kick-off meeting. First row, left to right: Dr. Jens Zotzel (N-ZYME), Alexander Webersinke (N-ZYME), Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Jascha Folk (TU Darmstadt). Second row, left to right: Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Prof. Warzecha (TU Darmstadt), Dr. Gunter Eckert (GU).
Picture 2 (at the conference table): Members of the 'BMBF-KMU Innovativ' Consortium discuss the “NeurOliv” project Left to right: Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Dr. Jens Zotzel (N-ZYME), Dr. Gunter Eckert (GU), Jascha Folk (TU Darmstadt), Prof. Warzecha (TU Darmstadt), Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Alexander Webersinke (N-ZYME).
Goethe University is a research-oriented university in the European financial centre Frankfurt Founded in 1914 with purely private funds by liberally-oriented Frankfurt citizens, it is dedicated to research and education under the motto "Science for Society" and to this day continues to function as a "citizens’ university". Many of the early benefactors were Jewish. Over the past 100 years, Goethe University has done pioneering work in the social and sociological sciences, chemistry, quantum physics, brain research and labour law. It gained a unique level of autonomy on 1 January 2008 by returning to its historic roots as a privately funded university. Today, it is among the top ten in external funding and among the top three largest universities in Germany, with three clusters of excellence in medicine, life sciences and the humanities.
Publisher The President of Goethe University, Marketing and Communications Department, 60629 Frankfurt am Main
Editor: Dr. Anke Sauter, Science Editor, International Communication, Tel: +49(0)69 798-12498, Fax +49(0)69 798-761 12531, firstname.lastname@example.org
Dr. Anke Sauter | idw - Informationsdienst Wissenschaft
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Materials Sciences
19.10.2017 | Materials Sciences
19.10.2017 | Physics and Astronomy