What are the substances contained in olives that protect against memory loss? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University (TU) of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project “NeurOliv” is funded by the German Federal Ministry of Education and Research.
It has long been proven that people who follow a Mediterranean diet and keep physically and mentally active are less likely to suffer from dementia. Olives in particular appear to play a key role in this regard.
Members of the BMBF project “NeurOliv” gather for the project’s kick-off meeting. First row, left to right: Dr. Jens Zotzel (N-ZYME), Alexander Webersinke (N-ZYME), Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Jascha Folk (TU Darmstadt). Second row, left to right: Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Prof. Warzecha (TU Darmstadt), Dr. Gunter Eckert (GU).
But just what are the substances contained in these small, oval fruit that are so valuable? This is what a Hessen-based group of researchers from the Goethe University Frankfurt, the Technical University (TU) of Darmstadt and Darmstadt company N-Zyme BioTec GmbH intends to find out. The three-year project “NeurOliv” has a project volume of 1.3 million Euros and is funded by the Federal Ministry of Education and Research as part of the high-tech initiative "KMU-innovativ Biochance".
This collaboration combines a number of approaches, the initiative of which came from N-Zyme BioTec GmbH. The aim is to use substances contained in olives to develop new functional food for the ageing society, which will protect against Alzheimer’s disease.
“We want to test whether olive polyphenols can even help to cure the disease. This is why we believe our products also relate to the pharmaceutical sector”, says Dr. Joachim Tretzel, Managing Director of N-Zyme BioTec GmbH. The high-tech initiative of the German government was set up to fund small and medium-sized enterprises.
The team, led by Prof. Heribert Warzecha of the Department of Biology of TU Darmstadt, is examining the development of new biotechnological processes designed to extract specific plant substances. With the relevant genetic information, bacterial cultures are said to help bring out substances in a pure and defined form.
“Our new techniques make it easier to extract substances from olive leaves and significantly improve low yields“, explains Warzecha. “When it comes to production, this means we aren’t dependent on the seasonal harvesting of olives in growing areas”, adds Dr. Stefan Marx, also Managing Director of N-Zyme BioTec.
The “nutritional-neuroscience” working group of Dr. Gunter Eckert, food chemist and private lecturer at the Goethe University Frankfurt (GU), will test the effectiveness of these biotechnologically produced olive substances. Firstly, olive substances will be tested in cell culture models, which may protect against Alzheimer’s disease. “We focus on changes to the power houses of nerve cells (mitochondria), which change early on in Alzheimer’s disease”, says Eckert. The most active compounds should then demonstrate in a mouse model of the disease that they can improve brain function.
“We are testing the hypothesis that certain polyphenols from olives slow down disease processes in the brain, improve mitochondrial dysfunction and, as a result, provide evidence to suggest they protect against Alzheimer’s disease”, explains pharmacological expert Eckert, summarizing the objective of his research. GU researchers have been awarded funding of 288,000 Euros for the project. In another research project, Eckert is examining the relationship between diet and exercise with regard to the development of Alzheimer’s disease.
Dr. Gunter Eckert, Goethe University, Tel. +49 (0)69 798-29378, E-Mail firstname.lastname@example.org; Dr. Stefan Marx, N-Zyme BioTec GmbH Tel. +49 (0)6151 3912-772, E-Mail: email@example.com; Prof. Dr. Heribert Warzecha, TU Darmstadt, Tel. +49 (0)6151) 16-20900, E-Mail: firstname.lastname@example.org
Download images from: www.uni-frankfurt.de/54645204
Picture 1 (standing in front of the building): Members of the BMBF project “NeurOliv” gather for the project’s kick-off meeting. First row, left to right: Dr. Jens Zotzel (N-ZYME), Alexander Webersinke (N-ZYME), Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Jascha Folk (TU Darmstadt). Second row, left to right: Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Prof. Warzecha (TU Darmstadt), Dr. Gunter Eckert (GU).
Picture 2 (at the conference table): Members of the 'BMBF-KMU Innovativ' Consortium discuss the “NeurOliv” project Left to right: Alla Sarafeddivo (N-ZYME), Christopher Fuchs (N-ZYME), Dr. Jens Zotzel (N-ZYME), Dr. Gunter Eckert (GU), Jascha Folk (TU Darmstadt), Prof. Warzecha (TU Darmstadt), Dr. Stefan Marx (N-ZYME), Dr. Joachim Tretzel (N-ZYME), Alexander Webersinke (N-ZYME).
Goethe University is a research-oriented university in the European financial centre Frankfurt Founded in 1914 with purely private funds by liberally-oriented Frankfurt citizens, it is dedicated to research and education under the motto "Science for Society" and to this day continues to function as a "citizens’ university". Many of the early benefactors were Jewish. Over the past 100 years, Goethe University has done pioneering work in the social and sociological sciences, chemistry, quantum physics, brain research and labour law. It gained a unique level of autonomy on 1 January 2008 by returning to its historic roots as a privately funded university. Today, it is among the top ten in external funding and among the top three largest universities in Germany, with three clusters of excellence in medicine, life sciences and the humanities.
Publisher The President of Goethe University, Marketing and Communications Department, 60629 Frankfurt am Main
Editor: Dr. Anke Sauter, Science Editor, International Communication, Tel: +49(0)69 798-12498, Fax +49(0)69 798-761 12531, email@example.com
Dr. Anke Sauter | idw - Informationsdienst Wissenschaft
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy