Prostate cancer is one of the most common tumours affecting the male population, and a digital rectal examination is the main method for an early detection.
Several years ago, prostate specific antigen (PSA) levels where introduced as a diagnostic test and follow-up of the disease, but there are alternative situations such as manipulation of the prostate gland in a biopsy or a rectal exam, and other benign diseases like hyperplasia, that cause a temporary elevation of PSA levels leading to false positives.
The opposite is also true, since normal levels of PSA have been measured in patients suffering the tumoural pathology. Therefore the prostate specific antigen is not an indication of the degree of development of the disease.
The researchers of the department of genetics and cell biology at the University of Alcalá decided to look for new prognostic markers that together with the PSA would increase the diagnostic specificity of the disease. The molecules selected for the study where Proinflammatory Cytokines that already play an important role in the development of the cancer. Their work consisted in relating the expression of different Proinflammatory Cytokines, Interleuquines 1 & 6 and the necrosis factor-alpha (TFN-a), with the levels of prostate specific antigen (PSA) in blood serum, both for normal patients (without tumoural pathology), as well as for pathologic conditions (hyperplasia and cancer), while also relating them to their role in tumour progression as stated by Mar Royuela.
To achieve this, they studied prostate samples of healthy patients with benign hyperplasia and with prostate cancer in collaboration with the researchers from the Université du 7 Novembre à Carthage of Tunisia. The results of the study, published in the journal Cancer detection and prevention, indicate that there could be a link between high expression of Proinflammatory Cytokines IL-1, TNF- a and IL-6 and high seric levels of PSA with the progression of the cancer. It is possible that a better understanding of the biological mechanism of such an association could lead to a therapeutic target in patients suffering from a prostate pathology, as the professor of Alcalá University explains.
The research group for solid tumour cellular biology and tissue regeneration at the UAH has dedicated over 10 years to the study of histology and cellular biology of the healthy and anomalous human prostate; work that was complemented by the study of breast cancer. Their line of thinking focuses on the intermediaries in the different transduction paths initiated by the TNF-alpha/ IL-1 that activate different transcription factors involved in cellular proliferation. “Cancer is a complex process that involves many factors. Only by knowing most of them we will be able to find an effective therapy”, Professor Royuela states. “In order to achieve this objective the investigation must continue. In our case, we propose to study one of bifurcations in the transcription routes which lead to the activation of NF-kB. In the future, we will complement our research with the study of the link between these paths and the family of proteins that inhibits apoptosis (cell death) and which acts mainly on caspases”, concludes the researcher of Alcalá University.
Oficina Información Científica | alfa
Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center
Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
22.09.2017 | Life Sciences
22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy