Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Progress in the development of new Parkinson’s drugs

22.10.2010
The side effects of the standard medication for Parkinson’s disease have long been a preoccupation of brain researchers. Now Daniella Rylander has presented new findings in a recently defended PhD thesis at Lund University that provide hope of more effective medication for those who suffer from the nerve cell disease.

In her thesis, neuroscience researcher Daniella Rylander presents two important findings that tackle different stages in the development of the uncontrollable jerky movements known as dyskinesia, which are an undesirable effect of treatment with the standard drug levodopa.

Dr Rylander has studied two different systems in the brain that are believed to play an important role in the development of the side effects – glutamate and serotonin. An overactivation of glutamate signals, caused by treatment with levodopa, probably contributes to the development of dyskinesia. Daniella Rylander’s research focuses on blocking this undesirable overactivation.

“The receptor cells have different receptors on their surface where the glutamate is taken in to activate the cell. It is these receptors that I have tried to block. If we could find the right channel and subdue it then we could get more effective treatment with levodopa without any side effects. This has always been my goal”, says Daniella Rylander.

Tests in animal models, including rats, have shown very good results for the new method. A drug that blocks glutamate overactivation via the glutamate receptor ‘mGluR5’ was used in the study. This has previously been tested on humans and so provides a head start in the time-consuming clinical trials required before a new drug can be introduced.

Serotonin also plays an important role in the development of dyskinesia in Parkinson’s disease.

“We have now shown for the first time that individuals who have a particularly large amount of a certain type of fibre on their serotonin cells are also at greater risk of being affected by dyskinesia after levodopa treatment”, says Daniella Rylander.

The new finding of a clear pathological change in the serotonin system can now be utilised to better tailor the individual treatment of patients with Parkinson’s disease.

Daniella Rylander, who is part of the Basal Ganglia Pathophysiology Unit research group, defended her PhD thesis on 17 September 2010. The thesis is entitled Involvement of non-dopaminergic systems in L-DOPA-induced dyskinesia.

To contact Daniella Rylander: tel. +46 (0)46 222 36 19, Daniella.Rylander@med.lu.se

Pressofficer Megan Grindlay; +46-46 222 7308; megan.grindlay@fie.lu.se

Megan Grindlay | idw
Further information:
http://www.lunduniversity.lu.se/o.o.i.s?id=12683&postid=1659459
http://www.med.lu.se/english/expmed/research/basal_ganglia_pathophysiology

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>