Limited clinical trials using an innovative new device to monitor brain chemistry on a second-by-second basis are underway to answer that life-and-death question, according to an article in the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. Brain injury is the leading cause of death and disability worldwide.
C&EN Senior Editor Celia Henry Arnaud describes a phenomenon called depolarization, in which brain activity decreases in patients following initial trauma. The condition involves a wave of chemical changes that spread from the site of injury and inactivate nerve cells.
Since reactivation of these cells requires large amounts of glucose, monitoring glucose levels in a patient's brain can help doctors tell whether or not a patient is taking a turn for the worse. The article points out that a promising new device could provide a faster and more useful way to monitor brain glucose than current methods, which are inefficient.
Now in development at Imperial College London, the new so-called "microfluidic method" measures glucose quickly and continuously — in fractions of a second instead of hourly.
The device is currently being tested in patients who have suffered trauma, stroke, or aneurysm (a balloon-like enlargement of a brain artery). In the future, the device could be used in patients with milder forms of brain injury and used in a way that is less invasive, the article notes.ARTICLE FOR IMMEDIATE RELEASE
Michael Bernstein | EurekAlert!
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There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
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So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
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