Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Premium car research & cow dung point to new high tech disease diagnosis

14.10.2009
Researchers at the University of Warwick have taken high tech gas sensors normally used to test components for premium cars and applied the same techniques to human blood, human urine, and even cow dung samples from local cow pats.

The results could lead to a new high tech medical tool that could provide a fast diagnosis for some of the most difficult gastrointestinal illnesses and metabolic diseases.

Fermentation of undigested foods in the colon by its resident bacteria affects not only colonic health (protection against inflammation and tumour formation) but also influences metabolic health. Studying fermentation and the volatile organic compounds (VOCs) it generates directly is difficult due to lack of easy access to the colon.

Researchers from the University of Warwick’s innovation specialists WMG have devised a solution to this problem using a special suite of equipment normally used to test car components for premium cars. The equipment heats car material samples to see what range of “volatile chemicals” (essentially gases) are emitted from car components to understand what implications that would have for air quality in the car and how it might affect the future recycling of the component. The car researchers wondered if this high tech equipment for studying volatile chemicals in premium cars would also assist their medical colleagues seeking to study volatile organic compounds from the human colon.

The University of Warwick WMG researchers Dr Mark Pharaoh and Dr Geraint J. Williams invited medical consultant Dr Ramesh P Arasaradnam (a Clinician Scientist and Lecturer in Gastroenterology in Warwick Medical School and a Gastroenterologist at University Hospitals Coventry & Warwick) to work with them to advise on how they could test their equipment on organic matter. Professors Sudesh Kumar, Chuka Nwokolo and K D Bardhan, from Warwick Medical School, also joined the team.

The gas products of fermentation include various volatile organic compounds, the relative proportions of which may change in disease. The research team have coined the term ‘fermentome’ to describe the complex interplay between diet, symbiont bacteria and volatile gases The clinical researchers in the team believed that the research engineer’s equipment could help them study such a ‘fermentome’ which could then be used for diagnosis and disease characterisation. Measurement of VOCs through non-invasive methods could then have an important application as a hypothesis-generating tool and could even have clinical applications.

The joint clinician and engineering research team have now performed tests using the car analysis equipment on human blood, human urine, and even cow and horse dung harvested from the local area. The results so far suggest that the equipment could indeed be used to obtain a useful picture of the range of fermentation gases produced by this organic matter. Knowing what those mix of gases are could therefore provide a useful analogue understanding of what gastrointestinal illness or metabolic diseases are afflicting patient.

The team have just published that research in a paper entitled “Colonic fermentation – More than meets the nose” in the journal Med Hypotheses. The research team are now exploring funding options that would allow them to take this new technique into a larger scale studies including clinical trials.

Dr Mark Pharaoh said:

“These early results suggest that we could indeed use this automotive technology to give medical consultants a very precise understanding of the mix of gases being produced within the human gut. An understanding of the precise mix of gases is a very valuable clue to understanding any problem with the balance and mix of bacteria that are generating those gases.”

Dr Ramesh P Arasaradnam said:

“This is could be a vital new tool in the diagnosis of gastrointestinal as well as metabolic diseases. Gaining first hand information of what is going on in the gut would require very invasive procedures. Even simply culturing the bacteria from a patient’s urine or faeces takes a considerable amount of time. This technique could give medical consultants such as myself valuable information about what is causing a patient’s condition long before the data from a standard bacterial culture would be available.”

The research team are now exploring funding options that would allow them to take this new technique into a clinical trial

Note for Editors:

The research paper just published in "Medical Hypotheses "- doi:10.1016/j.mehy.2009.04.027 is entitled : “Colonic fermentation – More than meets the nose”. The researchers are: Dr Mark Pharaoh and Dr Geraint J. Williams from the University of Warwick (WMG); Dr Ramesh P Arasaradnam, Professor Sudesh Kumar and Professor C.U. Nwokolo from Warwick Medical School and University Hospitals Coventry & Warwick; Prof K D Bardhan from Warwick Medical School, University of Warwick and Rotherham General Hospital.

For further information contact:

Dr Mark Pharaoh, University of Warwick, WMG
Tel: +44 (0)24 76 523941
m.w.pharaoh@warwick.ac.uk
Ramesh P Arasaradnam., Clinician Scientist and Lecturer in Gastroenterology
Warwick Medical School, University of Warwick, and University Hospitals Coventry & Warwick Tel: 02476 966087

E mail: r.arasaradnam@warwick.ac.uk

Peter Dunn, Head of Communications,

University of Warwick Tel: +44 (0)24 76 523708
or mobile/cell +44(0)7767 655860 email: p.j.dunn@warwick.ac.uk

Peter Dunn | EurekAlert!
Further information:
http://www.warwick.ac.uk

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>