Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Potential new target for drugs to treat iron deficiency and overload discovered

28.01.2010
The discovery of a major player in the body's regulation of iron levels should provide a new target for drugs that prevent common iron deficiency as well as rare, potentially deadly iron overload, researchers said.

Medical College of Georgia researchers noted in the online edition of Blood that the protein neogenin, a receptor that aids in neural development, is also part of the body's interwoven regulatory process for iron. The receptor, located on the cell surface, should be an easy target for drug development to help increase or decrease iron levels as needed, said Dr. Wen-Cheng Xiong, the study's corresponding author and a developmental neurobiologist at the Medical College of Georgia Schools of Medicine and Graduate Studies.

Iron, an essential nutrient in foods such as meats, beans and spinach, is used by all cells but primarily helps red blood cells deliver oxygen throughout the body. However, in some individuals, low levels cause iron deficiency-anemia while genetic diseases such as juvenile hemochromatosis or blood transfusions can result in toxic levels of iron in the body.

In the brain, neogenin works with other molecules to heard neurons in the right direction. One of those molecules, repulsive guidance molecules, or RGMs, are already known to help regulate iron levels, which led MCG researchers to suspect neogenin had a role as well.

Studies in mice showed neogenin inhibits secretion of an RGM gene called hemojuvelin. That reduces the signaling of a protein that reduces expression of hepcidin, a hormone released by the liver to control circulating iron levels by storing it in the spleen until it is needed and directing the intestines on how much iron to absorb or eliminate. In cells in culture, researchers consistently found that increased expression of hemojuvelin increases hepcidin expression while suppression decreases it.

Next steps include determining whether neogenin expression is up or down in patients with iron-related issues such as anemia or juvenile hemochromatosis.

"If that is verified, drugs to stimulate or inhibit neogenin would be useful," Dr. Xiong said. She predicts that neogenin expression will be increased in patients with iron deficiency anemia and decreased in iron-overload conditions.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

Further reports about: College Medical Wellness RGM Xiong blood cell genetic disease iron levels

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>