A recently published study suggests that exposure to social stress not only impairs a mother's ability to care for her children but can also negatively impact her daughter's ability to provide maternal care to future offspring.
Researchers at the Cummings School of Veterinary Medicine at Tufts University conducted a transgenerational study with female rats, examining the behavioral and physiological changes in mothers exposed to chronic social stress early in life as a model for postpartum depression and anxiety.
A different male rat was placed in the cage of the first-generation mothers and their newly born pups for an hour a day for 15 days. Consistent with previous research, the lactating mother rats responded to the stress of the intruder with depressed maternal care, impaired lactation, and increased anxiety. The pups of these mothers were also exposed to the conflict between their mothers and the male intruders.
After reaching maturation, second-generation females were mated and compared to a control group where neither the mother nor the pups had been exposed to a male intruder. The second generation mothers that experienced the early life stress also displayed depressed maternal care, impaired lactation, and increased anxiety. There were also changes to hormone levels: an increase in the stress hormone corticosterone, and decreases in oxytocin, prolactin (important to both maternal behavior and lactation) and estradiol.
"The endocrine and behavioral data are consistent with what has been reported in studies of depressed human mothers. The potential with this animal model is that it can be used to study new preventive measures and treatments for postpartum depression and anxiety, and the adverse effects of these disorders on offspring," said Benjamin C. Nephew, Ph.D., assistant professor in the Department of Biomedical Sciences at TCSVM and principal investigator of the study.
The study was published in the September issue of Hormones and Behavior.
"The chronic social stress model used in this study provides insight into how social stress affects both human and animal behavior in the areas of maternal care, anxiety and lactation, and provides a wealth of observations," said Lindsay M. Carini, the study's lead author.
Funding for the study came from the National Institute of Child Health and Human Development and the Tufts Clinical and Translational Science Institute.
This work builds off earlier Tufts research in the area of reproductive biology, which includes initial findings on the effects of chronic social stress on maternal behavior which was published in Stress by Nephew and Professor of Biomedical Sciences Robert Bridges, Nephew's postdoctoral mentor at TCSVM.
Carini, Lindsay M., Nephew, Benjamin C., Eﬀects of early life social stress on endocrinology, maternal behavior, and lactation in rats, Hormones and Behavior (2013), doi: 10.1016/j.yhbeh.2013.08.011.About the Cummings School of Veterinary Medicine at Tufts University
Rushmie Nofsinger | EurekAlert!
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy