Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Plenty of vitamin D helps prevent hip fractures in old age

05.07.2012
Recommendations of Federal Office of Public Health reinforced
The risk of suffering a hip fracture increases continuously from the age of 65 because our bones become weaker and more fragile the older we get. A study sponsored by the Swiss National Science Foundation (SNSF) has shown that vitamin D helps to prevent hip fractures, albeit only in high doses (800 units or more per day).

Healthy bones regenerate by absorbing calcium and phosphate continuously with the help of vitamin D. In the absence of vitamin D, bones become brittle. This often happens in old age, when the skin starts to lose its ability to produce vitamin D from the energy in sunlight. This is why three-quarters of all fractures occur in people over the age of 65. This age category is growing fast in Europe, and we are likely to see the number of hip fractures double by 2050.

Conflicting results
Several clinical trials have looked at whether the number of hip fractures and the horrendous costs associated with them can be reduced by administering prophylactic vitamin D. The results have been inconsistent. Researchers working with Heike Bischoff-Ferrari from the Centre on Ageing and Mobility at Zurich University have now produced a new overview of the data. Their meta-analysis(*), published recently in the New England Journal of Medicine, manages to resolve the contradictions.
Bischoff-Ferrari and her colleagues at Zurich University Hospital and Waid City Hospital looked at the original data generated from slightly over 30,000 elderly people who had taken part in eleven different clinical trials of vitamin D supplementation. Theirs was the first analysis to take account of the fact that some people had taken fewer vitamin D drops than intended while others had taken additional vitamin D outside the clinical trial.

Disputed dose-effect relationship
The group working with Bischoff-Ferrari demonstrated a dose-effect relationship that had hitherto been disputed. They found that vitamin D only has a protective effect if it is taken in large enough quantities. The risk of a hip fracture was thirty percent lower in people who had taken at least 800 international units (IU) of vitamin D every day.
This dosage level benefits both fragile senior citizens and those who are in good health and still living at home. "At the moment, our study is the most significant evidence base supporting the high dosage for elderly individuals recommended by the Federal Office of Public Health," Bischoff-Ferrari commented.

(*)Heike A. Bischoff-Ferrari, Walter C. Willett, Endel J. Oray, Paul Lips, Pierre J. Meunier, Ronan A. Lyons, Leon Flicker, John Wark, Rebecca D. Jackson, Jane A. Cauley, Haakon E. Meyer, Michael Pfeifer, Kerrie M. Sanders, Hannes B. Stähelin, Robert Theiler and Bess Dawson-Hughes (2012). A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention. New England Journal of Medicine 367: 40-49.
(Available as a PDF from the SNSF; E-mail: com@snf.ch)

Contact
Prof. Heike Annette Bischoff-Ferrari, MD
Zentrum Alter und Mobilität
Rheumaklinik, Universitätsspital Zürich
Gloriastrasse 25
CH-8091 Zürich
Tel.: +41 (0)44 255 26 99
E-mail: heike.bischoff@usz.ch

Communication division SNSF | idw
Further information:
http://www.snsf.ch

Further reports about: Medicine SNSF Vitamin D clinical trials health services hip fracture

More articles from Health and Medicine:

nachricht Spanish scientists create a 3-D bioprinter to print human skin
24.01.2017 | Carlos III University of Madrid

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>