Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Platelets block HIV

23.07.2013
Scientists of the DPZ have shown that platelet activation inhibits the host cell entry of HIV

Infection biologists of the German Primate Center (DPZ) under the direction of Stefan Pöhlmann have found evidence that platelets (thrombocytes) might constitute an innate defense against infection with the human immunodeficiency virus (HIV). HI-viruses are the cause of the immune deficiency disease AIDS.

In cooperation with colleagues from the Hannover Medical School and the Institute of Molecular Virology, Ulm University Medical Center, the scientists of the DPZ have shown in a recent study that platelet activation suppresses HIV type 1 (HIV-1) infection of cell cultures and might thus reduce viral spread in patients. The paper was published in the scientific journal Retrovirology.

Platelets, the smallest particles of the blood, are activated through contact with the vascular connective tissue, which leads to a change of their shape and the release of biological active substances from inside the platelets. One of these substances is the messenger protein CXCL4, which blocks the host cell entry of HIV-1. This finding was reported in 2012 by Auerbach and colleagues, National Institute of Allergy and Infectious Diseases, Bethesda, USA, for purified CXCL4. The efficiency of HIV-1 inhibition by platelets in patients is currently unclear and might depend on platelet numbers and activation status.

There are two types of the HI-virus: HIV-1 and HIV-2. Additionally, there is a closely related virus, which occurs in monkeys and apes – the simian immunodeficiency virus (SIV). The current study has demonstrated that HIV-1 is inhibited upon platelet activation while HIV-2 and SIV are not. HIV-1 is the most frequent and also the most aggressive type of HI-virus.

“Our research indicates that platelets might constitute an innate barrier against HIV-1 infection, a function that was largely unknown“, says Stefan Pöhlmann, head of the Infection Biology Unit at the German Primate Center and senior author of the new study. “Further research needs to uncover how efficiently CXCL4 released by platelets inhibits HIV-1 spread in patients. Another goal should be to identify substances with a CXCL4-like antiviral activity and to develop them as novel therapies against HIV-1 infection.”

Original publication:
Theodros Solomon Tsegaye, Kerstin Gnirß, Niels Rahe-Meyer, Miriam Kiene, Annika Krämer-Kühl, Georg Behrens, Jan Münch & Stefan Pöhlmann (2013): Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 10: 48.

Contact:

Prof. Dr. Stefan Pöhlmann
Tel: +49 551 3851-150
E-Mail: spoehlmann@dpz.eu
Astrid Slizewski (Stabsstelle Kommunikation)
Tel: +49 551 3851-359
E-Mail: aslizewski@dpz.eu
The German Primate Center (DPZ) in Göttingen, Germany, conducts basic research on and with primates in the areas of infectious diseases, neurosciences and organismic biology. In addition, it operates four field stations abroad and is a competence and reference center for primate research. The DPZ is one of the 86 research and infrastructure institutions of the Leibnitz Association in Germany.

Astrid Slizewski | idw
Further information:
http://www.dpz.eu

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>