Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Platelets block HIV

23.07.2013
Scientists of the DPZ have shown that platelet activation inhibits the host cell entry of HIV

Infection biologists of the German Primate Center (DPZ) under the direction of Stefan Pöhlmann have found evidence that platelets (thrombocytes) might constitute an innate defense against infection with the human immunodeficiency virus (HIV). HI-viruses are the cause of the immune deficiency disease AIDS.

In cooperation with colleagues from the Hannover Medical School and the Institute of Molecular Virology, Ulm University Medical Center, the scientists of the DPZ have shown in a recent study that platelet activation suppresses HIV type 1 (HIV-1) infection of cell cultures and might thus reduce viral spread in patients. The paper was published in the scientific journal Retrovirology.

Platelets, the smallest particles of the blood, are activated through contact with the vascular connective tissue, which leads to a change of their shape and the release of biological active substances from inside the platelets. One of these substances is the messenger protein CXCL4, which blocks the host cell entry of HIV-1. This finding was reported in 2012 by Auerbach and colleagues, National Institute of Allergy and Infectious Diseases, Bethesda, USA, for purified CXCL4. The efficiency of HIV-1 inhibition by platelets in patients is currently unclear and might depend on platelet numbers and activation status.

There are two types of the HI-virus: HIV-1 and HIV-2. Additionally, there is a closely related virus, which occurs in monkeys and apes – the simian immunodeficiency virus (SIV). The current study has demonstrated that HIV-1 is inhibited upon platelet activation while HIV-2 and SIV are not. HIV-1 is the most frequent and also the most aggressive type of HI-virus.

“Our research indicates that platelets might constitute an innate barrier against HIV-1 infection, a function that was largely unknown“, says Stefan Pöhlmann, head of the Infection Biology Unit at the German Primate Center and senior author of the new study. “Further research needs to uncover how efficiently CXCL4 released by platelets inhibits HIV-1 spread in patients. Another goal should be to identify substances with a CXCL4-like antiviral activity and to develop them as novel therapies against HIV-1 infection.”

Original publication:
Theodros Solomon Tsegaye, Kerstin Gnirß, Niels Rahe-Meyer, Miriam Kiene, Annika Krämer-Kühl, Georg Behrens, Jan Münch & Stefan Pöhlmann (2013): Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 10: 48.

Contact:

Prof. Dr. Stefan Pöhlmann
Tel: +49 551 3851-150
E-Mail: spoehlmann@dpz.eu
Astrid Slizewski (Stabsstelle Kommunikation)
Tel: +49 551 3851-359
E-Mail: aslizewski@dpz.eu
The German Primate Center (DPZ) in Göttingen, Germany, conducts basic research on and with primates in the areas of infectious diseases, neurosciences and organismic biology. In addition, it operates four field stations abroad and is a competence and reference center for primate research. The DPZ is one of the 86 research and infrastructure institutions of the Leibnitz Association in Germany.

Astrid Slizewski | idw
Further information:
http://www.dpz.eu

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>