Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Plasma levels of GGT and ALB and their genetic correlations with cardiovascular risk factors

26.11.2009
Two indicators of liver function, ƒ× glutamyl transferase (GGT) and albumin (ALB) have been implicated in the pathogenesis of atherosclerosis. It is known that the variation in the plasma level of these liver related proteins is genetically influenced.

The purpose of this study published in the December 2009 issue of Experimental Biology and Medicine was to identify chromosomal regions containing genes that affect the variation in the plasma levels of GGT and albumin and to determine whether genes contributing to variation in these hepatic proteins also influence variation in known cardiovascular disease risk factors.

This work was conducted by Tanushree Bose, at the time a graduate student in the Department of Nutritional Science at The University of Texas at Austin and currently a faculty member at California Polytechnic State University, and Anthony Comuzzie and colleagues in the Department of Genetics at the Southwest Foundation for Biomedical Research and the Southwest National Primate Research Center in San Antonio, Texas. The study utilized serum samples from 350 (254 females; 96 males) baboons from the pedigreed colony maintained by the Southwest National Primate Research Center. Dr. Bose noted that "Even though phenotypic correlations between ALB and cardiovascular risk factors have been reported the evidence of shared genetic effects (i.e. pleiotropy) between them has been reported for the first time in this paper".

Findings of this study will assist in future hypotheses aimed at identifying the relative contribution of various components to the pathogenesis of liver dysfunction. Additionally, if a common set of genes are found to regulate variation in levels of liver proteins and cardiovascular disease risk factors these experimental results can be used to develop future studies that will identify and explore those genes.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "The studies by Bose et al suggest that GGT and albumin are under significant genetic regulation and that a common genetic component influences both plasma albumin levels and cardiovascular disease risk factors. Now it will be essential to identify these genes".

Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit www.ebmonline.org.

Dr. Tanushree Bose | EurekAlert!
Further information:
http://www.sebm.org
http://www.ebmonline.org

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>