Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Peptic ulcer bacterium alters the body's defence system

30.06.2009
Helicobacter pylori survives in the body by manipulating important immune system cells. This is shown in a thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden. The discovery may lead to new treatments against the common peptic ulcer bacterium.

About half of the world's population carries Helicobacter pylori, mainly in the stomach. Most infected individuals never experience any symptoms, but around 10% get peptic ulcers and around 1% develop stomach cancer.

'Carriers were often infected as children and if not treated with antibiotics, the bacterium remains in the body for life. The immune system alone is unable to eliminate the bacterium, and now we understand better why', says biologist Bert Kindlund, the author of the thesis.

The study shows that a type of cells in the immune system called regulatory T cells down-regulate the body's defence against Helicobacter pylori and thereby enable the bacterium to develop a chronic infection. 'If we could control the regulatory T cells, we could strengthen the immune system and help the body eliminate the bacterium. This could be a new treatment strategy against Helicobacter pylori', Kindlund continues.

In addition, the bacterium makes the immune system increase the number of regulatory T cells in the lining of the stomach. This also occurs with stomach cancer. 'An important question is where the increased number of regulatory T cells in the stomach lining come from. Knowing the answer to this question could help us develop a treatment for stomach cancer. What we have found so far is that the regulatory T cells are actively recruited from the bloodstream into the tumour, and once there they start multiplying faster', says Kindlund.

For more information please contact:
Bert Kindlund, biologist, telephone +46 (0)73 535 49 96, e-mail bert.kindlund@microbio.gu.se
Supervisors:
Samuel Lundin, Associate Professor, telephone +46 (0)31 786 6207, e-mail samuel.lundin@microbio.gu.se

Åsa Sjöling, Associate Professor, telephone +46 (0)31 786 62 32, e-mail asa.sjoling@microbio.gu.se

A thesis presented for the degree of Doctor of Philosophy (Medicine) at the Sahlgrenska Academy, Institute of Biomedicine, Department of Microbiology and Immunology.

The thesis is based on the following papers:
I. Bert Kindlund, Åsa Sjöling, Malin Hansson, Anders Edebo, Lars-Erik Hansson, Henrik Sjövall, Ann-Mari Svennerholm and B. Samuel Lundin
FOXP3-expressing CD4+ T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4+ T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. Helicobacter 2009 June; 14 (3): 192-201
II. Karin Enarsson, Anna Lundgren, Bert Kindlund, Mikael Hermansson, Giovanna Roncador, Alison H Banham, B. Samuel Lundin and Marianne Quiding-Järbrink
Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin Immunol 2006 Dec; 121 (3): 358-68
III. B. Samuel Lundin, Karin Enarsson, Bert Kindlund, Anna Lundgren, Erik Johnsson, Marianne Quiding-Järbrink and Ann-Mari Svennerholm

The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10. Clin Immunol 2007 Nov; 125 (2) 205-13

Helena Aaberg | idw
Further information:
http://www.gu.se/

Further reports about: CD4+ Helicobacter pylori Peptic T cells T-cell immune system stomach cancer

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>