Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pain treatments less effective for those with irritable bowel

21.08.2014

University of Adelaide researchers have discovered that the immune system is defective in people suffering from irritable bowel syndrome, which is a major reason why sufferers have ongoing issues with pain.

The research – the first of its kind in the world – could also help to explain why some painkillers may not offer satisfactory relief to sufferers.

Irritable bowel syndrome (IBS) affects up to 10% of the community. There are different forms of IBS but all of them involve unexplained gut pain, which often has the greatest impact on sufferers' quality of life.

Scientists in the University's Nerve-Gut Research Laboratory have now demonstrated the mechanisms involved, and the differences between the immune pain response in healthy people and those suffering from IBS. The results of their work have been published in the journal Brain, Behavior and Immunity.

... more about:
»IBS »NHMRC »bowel »healthy »immune »involved »mechanisms »pain »symptoms »treat »treatments

"This study is the first to give us a real understanding of the interaction between the immune system and pain symptoms in IBS patients," says lead author Dr Patrick Hughes, NHMRC Peter Doherty Fellow with the University's School of Medicine.

"The gut contains specialised immune cells, known as monocytes and macrophages. Our research has shown that in healthy people, these immune cells normally secrete opioid chemicals, like morphine, that block pain. But in people with IBS, the opioid production by these cells is defective," he says.

"So it's no wonder that people with IBS are experiencing ongoing periods of unexplained pain. And if the immune system is defective, it may also mean that painkilling medications taken by the patient to relieve their symptoms are not being adequately converted to pain relief."

The research involved samples from more than 100 people, half of them healthy and half suffering from IBS.

Dr Hughes says the exact cause of pain in IBS sufferers remains unknown, "but we have now confirmed, and detailed, information about the important role of the immune system in this pain response".

"It's our hope that this work could eventually lead to more targeted treatments for IBS sufferers, to help treat or prevent the long-term pain they experience," he says.

###

This research has been supported by the National Health and Medical Research Council (NHMRC).

Patrick Hughes | European Geosciences Union

Further reports about: IBS NHMRC bowel healthy immune involved mechanisms pain symptoms treat treatments

More articles from Health and Medicine:

nachricht Fast-tracking T cell therapies with immune-mimicking biomaterials
16.01.2018 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht Dengue takes low and slow approach to replication
12.01.2018 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Novel 3-D printing technique yields high-performance composites

16.01.2018 | Materials Sciences

New application for acoustics helps estimate marine life populations

16.01.2018 | Life Sciences

Fast-tracking T cell therapies with immune-mimicking biomaterials

16.01.2018 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>