Total joint replacement is an effective treatment for severe knee and hip OA, and obesity is recognized as being the most important modifiable risk factor for OA. BMI is the most commonly used measurement of obesity but does not account for the pattern of fat distribution, and cannot discriminate between adipose and non-adipose tissue.
A research team headed by Flavia Cicuttini of the Monash University, Melbourne, Australia, conducted a prospective cohort study in 32,023 healthy volunteers to examine the relationship between different adiposity measures and the risk of subsequent primary knee and hip joint replacement. BMI, waist circumference and waist-to-hip ratios were measured, and fat mass and percentage fat were estimated.
The study determined that there was a 3 to 4-fold increased risk of primary joint replacement associated with body weight, BMI, fat mass and percentage fat. Waist circumference and waist-to-hip ratio were also associated with an increased risk, suggesting that both biomechanical and metabolic mechanisms associated with adiposity contribute to the risk of joint replacement. The group also showed that fat mass and percentage fat were associated with an increased risk of primary knee and hip joint replacement even 10 to 15 years after their measurement.
According to Cicuttini "Adipose mass contributes to increased joint loading, which may increase the risk of OA progression and subsequent joint replacement for severe end-stage OA. Metabolic factors are also likely to be important since waist circumference and waist-to-hip ratio are known risk factors for metabolic syndrome". She continues, "Adipose tissue is now considered an endocrine organ, releasing a multitude of factors, including cytokines which have been implicated in cartilage destruction".
The authors conclude, "The obesity epidemic occurring in developed countries is likely to have a significant impact on the future demands for knee and hip replacements for OA and understanding the mechanism of action will be important in effective prevention of OA".
Charlotte Webber | EurekAlert!
On track to heal leukaemia
18.01.2017 | Universitätsspital Bern
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
18.01.2017 | Power and Electrical Engineering
18.01.2017 | Materials Sciences
18.01.2017 | Life Sciences