Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Being overweight super-sizes both risk and consequences of sleep-disordered breathing

09.10.2009
Overweight individuals are not just at greater risk of having sleep-disordered-breathing (SDB), they are also likely to suffer greater consequences, according to new research.

According to the study, to be published in the October 15 issue of the American Journal of Respiratory and Critical Care Medicine, an official publication of the American Thoracic Society, excess weight increased the severity of oxygen desaturation in the blood of individuals with SDB during and after apneas and hypopneas.

"We knew that excess body weight is strongly related to more frequent breathing events—apneas and hypopneas—in persons with SDB," said lead author Paul E. Peppard, Ph.D., assistant professor of population health sciences at the University of Wisconsin-Madison. "In this study, we wanted to go a step further and measure how much the excess weight contributes to the severity of individual breathing events."

Dr. Peppard and colleagues recruited 750 adults from the Wisconsin Sleep Cohort study, an ongoing epidemiological investigation into the natural history of SDB, to have their breathing, blood-oxygen levels and sleep analyzed. Participants were also evaluated on several measures of physique—body mass index (BMI), neck -circumference and waist-to-hip ratio.

Among the participants in the overnight study, 40 percent of whom were obese, there were more than 37,000 SDB events. The researchers found that a number of factors influenced the severity of blood oxygen desaturation associated with these events, including age, gender, body position and sleep phase (REM or non-REM sleep). However, even after these other factors were accounted for, the researchers found that BMI predicted the degree to which the body's tissues were "starved" of oxygen during apneas and hypopneas. In fact, each 10-point increase in BMI predicted a 10 percent increase in the severity of oxygen depletion associated with SDB events.

"This means that if, for example, a six-foot tall, 160-pound 45-year-old man (BMI= 22), had an apnea that produced a six-percent reduction in oxygen saturation, then a man with the same characteristics who weighed 235 pounds (BMI=32) would be expected to have a 6.6 percent reduction in blood oxygen saturation during a similar event," explained Dr. Peppard. "This increased risk of more severe oxygen desaturation is not just associated with clinical obesity—any increase in weight above a BMI of approximately 25 appears to increase the risk and severity of SDB," he noted.

Mary Morrell, Ph.D., from the Imperial College London, who collaborated on the study, pointed out that of all the factors found to influence the severity of oxygen desaturation, being overweight is one of the only factors that is modifiable, suggesting it as a logical target for SDB interventions.

"These results reinforce the importance of excess weight as a risk factor for the development, progression and severity of SDB," said Dr. Peppard. "Clinicians should consider the possibility that particularly overweight patients might be experiencing severer consequences of SDB even if they have the same number of breathing events as less overweight patients."

While these findings represent an important step in understanding the consequences and risk factors associated with excess weight and SDB, Dr. Peppard emphasizes that more research is required to fully understand the issue. "Ongoing studies are looking into how, and to what degree, repeated oxygen desaturations produce poor clinical outcomes," he said. "We also need to assess the impact of the obesity epidemic on sleep apnea prevalence and severity in the general population. Our research group—the Wisconsin Sleep Cohort Study—is presently working on the latter question. Multiple research groups spanning basic science to population-level sciences are working on the former."

Keely Savoie | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>