Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Being overweight super-sizes both risk and consequences of sleep-disordered breathing

09.10.2009
Overweight individuals are not just at greater risk of having sleep-disordered-breathing (SDB), they are also likely to suffer greater consequences, according to new research.

According to the study, to be published in the October 15 issue of the American Journal of Respiratory and Critical Care Medicine, an official publication of the American Thoracic Society, excess weight increased the severity of oxygen desaturation in the blood of individuals with SDB during and after apneas and hypopneas.

"We knew that excess body weight is strongly related to more frequent breathing events—apneas and hypopneas—in persons with SDB," said lead author Paul E. Peppard, Ph.D., assistant professor of population health sciences at the University of Wisconsin-Madison. "In this study, we wanted to go a step further and measure how much the excess weight contributes to the severity of individual breathing events."

Dr. Peppard and colleagues recruited 750 adults from the Wisconsin Sleep Cohort study, an ongoing epidemiological investigation into the natural history of SDB, to have their breathing, blood-oxygen levels and sleep analyzed. Participants were also evaluated on several measures of physique—body mass index (BMI), neck -circumference and waist-to-hip ratio.

Among the participants in the overnight study, 40 percent of whom were obese, there were more than 37,000 SDB events. The researchers found that a number of factors influenced the severity of blood oxygen desaturation associated with these events, including age, gender, body position and sleep phase (REM or non-REM sleep). However, even after these other factors were accounted for, the researchers found that BMI predicted the degree to which the body's tissues were "starved" of oxygen during apneas and hypopneas. In fact, each 10-point increase in BMI predicted a 10 percent increase in the severity of oxygen depletion associated with SDB events.

"This means that if, for example, a six-foot tall, 160-pound 45-year-old man (BMI= 22), had an apnea that produced a six-percent reduction in oxygen saturation, then a man with the same characteristics who weighed 235 pounds (BMI=32) would be expected to have a 6.6 percent reduction in blood oxygen saturation during a similar event," explained Dr. Peppard. "This increased risk of more severe oxygen desaturation is not just associated with clinical obesity—any increase in weight above a BMI of approximately 25 appears to increase the risk and severity of SDB," he noted.

Mary Morrell, Ph.D., from the Imperial College London, who collaborated on the study, pointed out that of all the factors found to influence the severity of oxygen desaturation, being overweight is one of the only factors that is modifiable, suggesting it as a logical target for SDB interventions.

"These results reinforce the importance of excess weight as a risk factor for the development, progression and severity of SDB," said Dr. Peppard. "Clinicians should consider the possibility that particularly overweight patients might be experiencing severer consequences of SDB even if they have the same number of breathing events as less overweight patients."

While these findings represent an important step in understanding the consequences and risk factors associated with excess weight and SDB, Dr. Peppard emphasizes that more research is required to fully understand the issue. "Ongoing studies are looking into how, and to what degree, repeated oxygen desaturations produce poor clinical outcomes," he said. "We also need to assess the impact of the obesity epidemic on sleep apnea prevalence and severity in the general population. Our research group—the Wisconsin Sleep Cohort Study—is presently working on the latter question. Multiple research groups spanning basic science to population-level sciences are working on the former."

Keely Savoie | EurekAlert!
Further information:
http://www.thoracic.org

More articles from Health and Medicine:

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>