Overweight more harmful to the liver than alcohol in middle-aged men
Overweight carries a greatly increased risk of cirrhosis of the liver in men, reveals a new study from the Sahlgrenska Academy. “Given the increasing problem of overweight in Sweden, there is reason to fear that more people will develop cirrhosis of the liver,” says Jerzy Kaczynski, docent at the University of Gothenburg and doctor at Sahlgrenska University Hospital.
A group of researchers at the Sahlgrenska Academy has studied the link between overweight and the risk of developing cirrhosis of the liver in middle-aged men. Published in the Scandinavian Journal of Gastroenterology, the study took 855 men aged 50 and followed them for up to 40 years.
None of the men had liver problems at the beginning of the study but during the long follow-up period almost 2% were diagnosed with cirrhosis of the liver. All of the men with this diagnosis were overweight at the beginning of the study, with an average BMI of 28 (a BMI of above 25 is classified as overweight). The average BMI for the men who were not diagnosed with cirrhosis of the liver during the study was below 25. Statistical analysis has demonstrated that both BMI and raised levels of triglycerides – a type of blood fat – constituted risk factors for the development of cirrhosis of the liver. However, the same link could not be statistically proven for alcohol. One explanation for this could be that some men with alcohol problems may have declined to take part in the study.
The results of the study show that both overweight and raised levels of blood fats, which are common in overweight people, significantly increase the risk of men developing cirrhosis of the liver. Given the increasingly discussed and growing problem of overweight in Sweden, there are good grounds for concern that more people will be diagnosed with cirrhosis of the liver.
“A liver that has been ill and weakened as a result of overweight can take less of a load,” says Kaczynski. “We can therefore speculate that cirrhosis of the liver will develop more quickly in people who drink too much alcohol if they are overweight. Our study does not offer any evidence for this, but this kind of speculation is well founded.”
For more information, please contact:
Jerzy Kaczynski, Docent, Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, and doctor, Department of Medicine, Sahlgrenska University Hospital Östra, tel: +46 (0)31 343 5593, e-mail: firstname.lastname@example.org
Journal: Scandinavian Journal of Gastroenterology
Title of article: Overweight and hypertriglyceridemia are risk factors for liver cirrhosis in middle-aged Swedish men
Authors: Jerzy Kaczynski, Andreas Schult, Henry Eriksson and Sven Wallerstedt
Helena Aaberg | idw
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
New technique promises tunable laser devices
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...