Presented in the American Journal of Neurosurgery, the results are based on the world’s first study to demonstrate the effects of a shunt operation using a placebo control.
14 patients were followed for an average of three and a half years after the operation, with half being given a non-functioning shunt – in other words a sham operation – and the other half a functioning shunt. This is the equivalent to the placebo given in drug trials to determine how much of the treatment’s effect is down to the patient’s and others’ expectations.
“For obvious reasons, this is problematic in a surgical context and surgical placebo studies are highly unusual,” says Magnus Tisell, docent at the Sahlgrenska Academy and consultant neurosurgeon at Sahlgrenska University Hospital. “However, if you can actually do this kind of study, the level of evidence is the highest possible – class 1.”
The researchers found that patients’ mental functions and ability to walk improved tangibly after having a shunt inserted. Half were given an open shunt right from the start and showed immediate improvement, while the other half were initially given a closed shunt and improved only after three months when the shunt was opened.
“Shunt operations have long been used for hydrocephalus, but this study offers more scientifically conclusive results to support the effect of the treatment, and also shows that shunt operations can help far more patients than previously believed with their walking and memory,” says Tisell.
Surgery is not generally used today for patients with hydrocephalus and white matter changes. But the researchers’ findings pave the way for a brand new group of patients who could benefit from a shunt operation.
“We believe that far more patients than is currently the case could benefit from a shunt operation, which will require more resources,” says Tisell. “We also need to find out more about which patients are good candidates for the operation and which shunt is best in each particular case.”HYDROCEPHALUS
Helena Aaberg | idw
PET imaging tracks Zika virus infection, disease progression in mouse model
20.09.2017 | US Army Medical Research Institute of Infectious Diseases
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
20.09.2017 | Life Sciences
20.09.2017 | Power and Electrical Engineering
20.09.2017 | Physics and Astronomy