Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oestrogen treatment with no side-effects in sight

12.04.2011
Oestrogen treatment for osteoporosis has often been associated with serious side-effects. Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have now, in mice, found a way of utilising the positive effects of oestrogen in mice so that only the skeleton is acted on, current research at the Academy shows.

The study is presented in the respected journal PNAS (Proceedings of the National Academy of Sciences).

Many women are affected by osteoporosis after the menopause, when the body’s production of oestrogen decreases. Oestrogen is the hormone that principally strengthens the bone mass in women, and it is also of significance for the skeleton in men. Treatment of osteoporosis with oestrogens is, however, associated with serious side-effects such as breast cancer and blood clots. In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, the researchers have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.

Oestrogen has recipient molecules known as oestrogen receptors, which cause the body to respond to oestrogen.

”This is the first study to analyse the significance of different parts of a particular type of oestrogen receptor through studies in mice. It enables us to differentiate the favourable effects of oestrogen in bone tissue from the adverse effects in other tissues,” says Anna Börjesson, a PhD student at the Centre for Bone and Arthritis Research at the Sahlgrenska Academy.

This knowledge improves the prospects of being able to develop new, safer oestrogen treatments in the future.

”The development of special oestrogens that are tailored to bone and only affect a particular part of this type of oestrogen receptor may lead to a more targeted and effective treatment for osteoporosis with minimal side-effects,” Professor Claes Ohlsson explains.

FACTS ABOUT OSTEOPOROSIS
Sweden and Norway have the highest incidence of fractures due to osteoporosis in the world. Sweden and other industrialised countries face a significant increase in the number of osteoporosis fractures as the elderly population increases. Osteoporosis is the cause of 70 000 fractures in Sweden and costs the health service just under SEK 5 billion every year. These fractures often result in impaired mobility and great suffering for patients affected.
For further information, please contact:
Anna Börjesson, researcher at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3423183, mobile +46 (0)702-576918, e-mail: Anna.Borjesson@gu.se

Claes Ohlsson, Professor at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3422873, mobile +46 (0)706-832966, e-mail Claes.Ohlsson@medic.gu.se

Bibliographic data:
Journal: Proceedings of the National Academy of Sciences (PNAS)
Title of the article: Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone

Authors: Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C

Helena Aaberg | idw
Further information:
http://www.gu.se
http://www.pnas.org/content/early/2011/03/24/1100454108.abstract

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>