Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oestrogen treatment with no side-effects in sight

12.04.2011
Oestrogen treatment for osteoporosis has often been associated with serious side-effects. Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have now, in mice, found a way of utilising the positive effects of oestrogen in mice so that only the skeleton is acted on, current research at the Academy shows.

The study is presented in the respected journal PNAS (Proceedings of the National Academy of Sciences).

Many women are affected by osteoporosis after the menopause, when the body’s production of oestrogen decreases. Oestrogen is the hormone that principally strengthens the bone mass in women, and it is also of significance for the skeleton in men. Treatment of osteoporosis with oestrogens is, however, associated with serious side-effects such as breast cancer and blood clots. In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, the researchers have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.

Oestrogen has recipient molecules known as oestrogen receptors, which cause the body to respond to oestrogen.

”This is the first study to analyse the significance of different parts of a particular type of oestrogen receptor through studies in mice. It enables us to differentiate the favourable effects of oestrogen in bone tissue from the adverse effects in other tissues,” says Anna Börjesson, a PhD student at the Centre for Bone and Arthritis Research at the Sahlgrenska Academy.

This knowledge improves the prospects of being able to develop new, safer oestrogen treatments in the future.

”The development of special oestrogens that are tailored to bone and only affect a particular part of this type of oestrogen receptor may lead to a more targeted and effective treatment for osteoporosis with minimal side-effects,” Professor Claes Ohlsson explains.

FACTS ABOUT OSTEOPOROSIS
Sweden and Norway have the highest incidence of fractures due to osteoporosis in the world. Sweden and other industrialised countries face a significant increase in the number of osteoporosis fractures as the elderly population increases. Osteoporosis is the cause of 70 000 fractures in Sweden and costs the health service just under SEK 5 billion every year. These fractures often result in impaired mobility and great suffering for patients affected.
For further information, please contact:
Anna Börjesson, researcher at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3423183, mobile +46 (0)702-576918, e-mail: Anna.Borjesson@gu.se

Claes Ohlsson, Professor at the Centre for Bone and Arthritis Research, Sahlgrenska Academy, +46 (0)31-3422873, mobile +46 (0)706-832966, e-mail Claes.Ohlsson@medic.gu.se

Bibliographic data:
Journal: Proceedings of the National Academy of Sciences (PNAS)
Title of the article: Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone

Authors: Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C

Helena Aaberg | idw
Further information:
http://www.gu.se
http://www.pnas.org/content/early/2011/03/24/1100454108.abstract

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>