"OSA is known to be associated with inflammation and oxidative stress, so we hypothesized that it would be associated with peripheral neuropathy in patients with T2DM," said lead author Abd Tahrani, MD, clinical lecturer in endocrinology and diabetes at the University of Birmingham in the UK. "This is the first report to identify an independent association between OSA and DPN in these patients."
The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
In the observational cross-sectional study, DPN was assessed with the Michigan Neuropathy Screening instrument in 234 adults with T2DM. OSA was assessed with a single overnight home-based cardio-respiratory sleep study using a portable multi-channel device.
OSA was independently associated with DPN even after adjustment for a number of possible confounders, including ethnicity, gender, age at diabetes diagnosis, and diabetes duration, and remained independently associated with DPN after further adjustment for obesity and other risk factors for DPN. In addition, DPN severity was significantly correlated with OSA severity and nocturnal hypoxemia severity. The relationship between OSA severity and DPN severity remained significant after adjustment for age, obesity, diabetes duration, gender and estimated glomerular filtration rate.
The researchers also found that OSA was associated with increased nitrosative/oxidative stress and impaired microvascular blood flow regulation, which could explain the relationship observed between OSA and DPN. "In patients with T2DM, OSA may aggravate and amplify glucose toxicity, which has significant implications for tissues which are susceptible to the complications of diabetes," said Dr. Tahrani.
The study had some limitations, including its cross-sectional design and lack of an interventional arm, making proof of causation necessary in additional prospective studies.
"Additional prospective and interventional studies are also needed to examine the role of OSA and intermittent hypoxemia in the development and progression of DPN in patients with both early and advanced diabetes, and to assess the potential impact of continuous positive airway pressure (CPAP) treatment on DPN," Dr. Tahrani said.
About the American Journal of Respiratory and Critical Care Medicine:
With an impact factor of 10.191, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields.
Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.
Nathaniel Dunford | EurekAlert!
Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku
Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy