Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New genes for regulating the heart rhythm discovered


Cardiac arrhythmia is a frequent occurrence: according to the WHO, 33.5 million people all over the world are affected by atrial fibrillation - this being just one of many different kinds of arrhythmia.

A global research consortium, of which the EURAC Center for Biomedicine in Bozen-Bolzano is a member, has now identified 23 new genes which control both the heart rhythm and the length of the so-called QT interval. The study was further enhanced by data provided by participants from South Tyrol. The results, which open up new pathways for early diagnosis and treatment, have just been published in the medical journal “Nature Genetics”.

The QT interval is part of the heart’s electrical cycle as measured by ECG, and represents the electrical depolarization and repolarization of the ventricles. Lengthened intervals indicate dysfunction in the heart beat and are liable to lead to a five-fold increase in the risk of sudden death from heart failure. The underlying causes for such irregularities have not yet been fully explored. They are generally supposed to be due mainly to genetic factors.

In collaboration with research partners recruited from an international consortium, scientists from the EURAC Center for Biomedicine have evaluated the ECG results of over 100,000 study participants from Germany, Italy and the USA, as well as around 1,300 from South Tyrol who made their data freely available to the EURAC researchers. The scientists compared the QT intervals from the ECGs of all the study participants with their genetic variants in order to identify possible connections.

The result: they discovered 23 new genes which are linked to a lengthened QT interval. At the same time, they were able to demonstrate that the newly identified genes, which previously had not been thought to play a part in the heart rhythm, had a significant influence on the electrical activity of the heart muscle. In more in-depth studies with heart disease patients, the researchers could additionally determine that two of the newly identified genes were indeed risk factors for the disease known as “Long QT syndrome”.

“We still need to look more closely at the interplay of these genes with other risk factors, such as medication or life style. But one thing is certain: these findings have definitely brought us a great deal closer to recognising the causes of arrhythmia and sudden death from heart failure,” stress the two scientists Peter Pramstaller, manager of the EURAC Center for Biomedicine and his deputy, Andrew Hicks.

“With data from more than 100,000 participants in the study and the joint efforts of hundreds of international researchers, this represents one of the biggest global research projects on this topic to which we were able to contribute through both our scientific expertise as well as making data available from South Tyrol participants,” summarise Pramstaller and Hicks.

Another current study carried out by the EURAC Center for Biomedicine will provide further important insights into arrhythmia and sudden death from heart failure. Here, researchers are examining a protein, also identified in the QT study, which transports calcium within the cells in a pump-like action and can therefore be considered one of the most important proteins for a correctly functioning heart cell.

Weitere Informationen: - Article "Nature Genetics"

Laura Defranceschi | idw - Informationsdienst Wissenschaft
Further information:

Further reports about: ECG EURAC Genetics Nature death depolarization genes identify medication rhythm

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>