Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New genes for regulating the heart rhythm discovered

02.07.2014

Cardiac arrhythmia is a frequent occurrence: according to the WHO, 33.5 million people all over the world are affected by atrial fibrillation - this being just one of many different kinds of arrhythmia.

A global research consortium, of which the EURAC Center for Biomedicine in Bozen-Bolzano is a member, has now identified 23 new genes which control both the heart rhythm and the length of the so-called QT interval. The study was further enhanced by data provided by participants from South Tyrol. The results, which open up new pathways for early diagnosis and treatment, have just been published in the medical journal “Nature Genetics”.

The QT interval is part of the heart’s electrical cycle as measured by ECG, and represents the electrical depolarization and repolarization of the ventricles. Lengthened intervals indicate dysfunction in the heart beat and are liable to lead to a five-fold increase in the risk of sudden death from heart failure. The underlying causes for such irregularities have not yet been fully explored. They are generally supposed to be due mainly to genetic factors.

In collaboration with research partners recruited from an international consortium, scientists from the EURAC Center for Biomedicine have evaluated the ECG results of over 100,000 study participants from Germany, Italy and the USA, as well as around 1,300 from South Tyrol who made their data freely available to the EURAC researchers. The scientists compared the QT intervals from the ECGs of all the study participants with their genetic variants in order to identify possible connections.

The result: they discovered 23 new genes which are linked to a lengthened QT interval. At the same time, they were able to demonstrate that the newly identified genes, which previously had not been thought to play a part in the heart rhythm, had a significant influence on the electrical activity of the heart muscle. In more in-depth studies with heart disease patients, the researchers could additionally determine that two of the newly identified genes were indeed risk factors for the disease known as “Long QT syndrome”.

“We still need to look more closely at the interplay of these genes with other risk factors, such as medication or life style. But one thing is certain: these findings have definitely brought us a great deal closer to recognising the causes of arrhythmia and sudden death from heart failure,” stress the two scientists Peter Pramstaller, manager of the EURAC Center for Biomedicine and his deputy, Andrew Hicks.

“With data from more than 100,000 participants in the study and the joint efforts of hundreds of international researchers, this represents one of the biggest global research projects on this topic to which we were able to contribute through both our scientific expertise as well as making data available from South Tyrol participants,” summarise Pramstaller and Hicks.

Another current study carried out by the EURAC Center for Biomedicine will provide further important insights into arrhythmia and sudden death from heart failure. Here, researchers are examining a protein, also identified in the QT study, which transports calcium within the cells in a pump-like action and can therefore be considered one of the most important proteins for a correctly functioning heart cell.

Weitere Informationen:

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3014.html - Article "Nature Genetics"

Laura Defranceschi | idw - Informationsdienst Wissenschaft
Further information:
http://www.eurac.edu

Further reports about: ECG EURAC Genetics Nature death depolarization genes identify medication rhythm

More articles from Health and Medicine:

nachricht Discovery points to a new path toward a universal flu vaccine
03.07.2015 | Rockefeller University

nachricht "CCS Telehealth Ostsachsen", Germany's largest telemedicine project, goes online in Dresden
02.07.2015 | Universitätsklinikum Carl Gustav Carus Dresden

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Viaducts with wind turbines, the new renewable energy source

Wind turbines could be installed under some of the biggest bridges on the road network to produce electricity. So it is confirmed by calculations carried out by a European researchers team, that have taken a viaduct in the Canary Islands as a reference. This concept could be applied in heavily built-up territories or natural areas with new constructions limitations.

The Juncal Viaduct, in Gran Canaria, has served as a reference for Spanish and British researchers to verify that the wind blowing between the pillars on this...

Im Focus: X-rays and electrons join forces to map catalytic reactions in real-time

New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions

A new technique pioneered at the U.S. Department of Energy's Brookhaven National Laboratory reveals atomic-scale changes during catalytic reactions in real...

Im Focus: Iron: A biological element?

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and a half billion years ago.

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and...

Im Focus: Thousands of Droplets for Diagnostics

Researchers develop new method enabling DNA molecules to be counted in just 30 minutes

A team of scientists including PhD student Friedrich Schuler from the Laboratory of MEMS Applications at the Department of Microsystems Engineering (IMTEK) of...

Im Focus: Bionic eye clinical trial results show long-term safety, efficacy vision-restoring implant

Patients using Argus II experienced significant improvement in visual function and quality of life

The three-year clinical trial results of the retinal implant popularly known as the "bionic eye," have proven the long-term efficacy, safety and reliability of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

World Conference on Regenerative Medicine: Abstract Submission has been extended to 24 June

16.06.2015 | Event News

MUSE hosting Europe’s largest science communication conference

11.06.2015 | Event News

 
Latest News

Aluminum Clusters Shut Down Molecular Fuel Factory

06.07.2015 | Power and Electrical Engineering

Veja Mate Offshore orders 67 wind turbines including record long-term service

06.07.2015 | Press release

The quantum middle man

06.07.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>