Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New gene for bipolar disorder discovered

12.03.2014

First on top of the world and then in the depths of despair – this is what the extreme mood changes for people with bipolar disorder are like.

Under the direction of scientists from the University of Bonn Hospital, the Central Institute of Mental Health of Mannheim and the University of Basel Hospital, an international collaboration of researchers discovered two new gene regions which are connected with the prevalent disease. In this unparalleled worldwide study, the scientists are utilizing unprecedented numbers of patients. The results are now being published in the renowned journal "Nature Communications".


In the lab: Prof. Dr. Markus Nöthen, Director of the Institute of Human Genetics University of Bonn Hospital.

(c) Photo: Volker Lannert/Uni Bonn

Throughout the course of their lives, about one percent of the population suffers from bipolar disorder, also known as manic-depressive disorder. The patients undergo a veritable rollercoaster of emotions:

During extreme shifts, they experience manic phases with delusions of grandeur, increased drive and a decreased need for sleep as well as depressive episodes with a severely depressed mood to the point of suicidal thoughts. The causes of the disease are not yet fully understood, however in addition to psychosocial triggers, genetic factors play a large role.

"There is no one gene that has a significant effect on the development of bipolar disorder," says Prof. Dr. Markus M. Nöthen, Director of the Institute of Human Genetics of the University of Bonn Hospital. "Many different genes are evidently involved and these genes work together with environmental factors in a complex way."

Scale of the investigation is unparalleled worldwide

In recent years, scientists at the Institute of Human Genetics were already involved in decoding several genes associated with bipolar disorder. The researchers working with Prof. Dr. Marcella Rietschel from the Central Institute of Mental Health of Mannheim, Prof. Dr. Markus M. Nöthen from the University of Bonn Hospital and Prof. Dr. Sven Cichon from the University of Basel Hospital are now using unprecedented numbers of patients in an international research collaboration:

New genetic data from 2266 patients with manic-depressive disorder and 5028 control persons were obtained, merged with existing data sets and analyzed together. In total, data on the genetic material of 9747 patients were compared with data from 14,278 healthy persons. "The investigation of the genetic foundations of bipolar disorder on this scale is unique worldwide to date," says Prof. Rietschel from the Central Institute of Mental Health of Mannheim.

The search for genes involved in manic-depressive disorder is like looking for a needle in a haystack. "The contributions of individual genes are so minor that they normally cannot be identified in the 'background noise' of genetic differences," explains Prof. Cichon from the University of Basel Hospital.

Only when the DNA from very large numbers of patients with bipolar disorder are compared to the genetic material from an equally large number of healthy persons can differences be confirmed statistically. Such suspect regions which indicate a disease are known by scientists as candidate genes.

Two new gene regions discovered and three known gene regions confirmed

Using automated analysis methods, the researchers recorded about 2.3 million different regions in the genetic material of patients and comparators, respectively. The subsequent evaluation using biostatistical methods revealed a total of five risk regions on the DNA associated with bipolar disorder. Two of these regions were newly discovered:

The gene "ADCY2" on chromosome five and the so-called "MIR2113-POU3F2" region on chromosome six. The risk regions "ANK3", "ODZ4" and "TRANK1" have already been described in prior studies. "These gene regions were, however, statistically better confirmed in our current investigation - the connection with bipolar disorder has now become even clearer," says Prof. Nöthen.

The researchers are particularly interested in the newly discovered gene region "ADCY2". It codes an enzyme which is involved in the conduction of signals into nerve cells. "This fits very well with observations that the signal transfer in certain regions of the brain is impaired in patients with bipolar disorder," explains the human geneticist of the University of Bonn Hospital. With their search for genetic regions, the scientists are gradually clarifying the causes of manic-depressive disorder. "Only when we know the biological foundations of this disease can be also identify starting points for new therapies," says Prof. Nöthen.

The research is being sponsored by the Federal Ministry for Education and Research (BMBF) within the scope of the National Genome Research Network plus (NGFNplus) in the Integrated Genome Research Network MooDS (Systematic Investigation of the Molecular Causes of Major Mood Disorders and Schizophrenia) and through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme.

Publication: Mühleisen, Leber, Schulze et al., Genome-wide association study reveals two new risk loci for bipolar disorder, Nature Communications, DOI: 10.1038/ncomms4339

Contact information:

Prof. Dr. Markus M. Nöthen
Institute of Human Genetics
University of Bonn Hospital
Tel. +49 (0)228/28751101
E-Mail: markus.noethen@ukb.uni-bonn.de

Prof. Dr. Marcella Rietschel
Central Institute of Mental Health, Mannheim
Tel. +49 (0)621/17036051
E-Mail: marcella.rietschel@zi-mannheim.de

Prof. Dr. Sven Cichon
Department of Medical Genetics
University of Basel Hospital
Tel. +41 (0) 61 265 36 47
E-Mail: sven.cichon@usb.ch

Johannes Seiler | idw - Informationsdienst Wissenschaft

Further reports about: Genetics Health Mental bipolar discovered disorder explains genes healthy

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>