Researchers at the University of Luxembourg have identified potential new ways to test for the first signs of one of the most deadly types of cancer: colorectal cancer. They have found new “biomarkers”: molecules whose increased presence or absence in tissue suggests the development of tumorous cells. These indicators could help detect colorectal cancer at an early stage, predict its severity or even offer new treatments.
“Colorectal cancer is still one of the most frequent and deadliest cancers worldwide. But diagnosed in time it can be cured in 9 out of 10 cases”, said Professor Serge Haan from the Life Science Research Unit at the University of Luxembourg.
“Thus it is highly important to identify more sensitive and specific markers to improve early diagnosis as well as therapeutic strategies”.
The research team around Prof. Serge Haan and Dr. Elisabeth Letellier studied over 800 detailed results of tissue-analysis of both patients with various stages of colorectal cancer and healthy individuals.
They completed this study with original analysis of patient material from the Ontario Tumor Bank in Canada and the Integrated Biobank of Luxembourg.
The Luxembourg-based team were the first to see a significant reduction in certain proteins (specifically SOCS2 and SOCS6) in pre-cancerous and cancerous colorectal cells.
They concluded that especially SOCS2 could be a very sensitive, early diagnostic biomarker. Further analysis also revealed that this protein could even give an early prediction of the cancer’s severity.
SOCS stands for “Suppressor Of Cytokine Signalling”, regulatory proteins which are essential for normal cell growth.
There is increasing evidence that the loss of SOCS proteins plays a role in many cancers as this induce uncontrolled cell growth and tumour development. This study additionally strengthens the case for those proteins having tumour repressive potential.
These findings have been published in the renowned British Journal of Cancer. The research team included several Luxembourg biomedical research institutions: The National Health Laboratory, the Santé Public Research Centre and the Integrated Biobank of Luxembourg.
This study was financed by the Luxembourg Cancer Foundation. Further work is now needed to expand on these findings before they can be used clinically.
http://www.nature.com/bjc/journal/v111/n4/abs/bjc2014377a.html - Link to the publication
http://wwwen.uni.lu/recherche/fstc/life_sciences_research_unit - Life Sciences Research Unit at the University of Luxembourg
Sophie Kolb | idw - Informationsdienst Wissenschaft
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Life Sciences
19.10.2017 | Interdisciplinary Research
19.10.2017 | Earth Sciences