Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mystery solved of source of anti-cancer effects in pregnancy hormone

24.06.2014

University of Montreal scientists have identified a small molecule found in pregnant women’s urine that apparently blocks the growth of several types of cancers, including AIDS-related Kaposi’s sarcoma, which currently has no cure. Their study results will be presented Monday at the joint meeting of the International Society of Endocrinology and The Endocrine Society: ICE/ENDO 2014 in Chicago.

These findings resurrect a nearly 20-year controversy over whether human chorionic gonadotropin (hCG), a hormone produced in high amounts during pregnancy, or its core fragments, or something else yields anti HIV and cancer-fighting activity against Kaposi’s sarcoma tumors.

Some researchers in the mid-1990s reported that “clinical-grade” hCG—crude or partially purified preparations of hCG extracted from pregnant women’s urine—shrunk these AIDS tumors, but they later retracted their original claim that hCG itself was the active component responsible for activity against Kaposi’s sarcoma.

“The real compound has been elusive,” said principal investigator Tony Antakly, PhD, a biochemist at the University of Montreal, who said it has taken his small group of researchers more than 12 years to find the answer.

Early on, and shortly before this retraction, Antakly’s group tested highly purified or recombinant hCG in Kaposi’s sarcoma cells and found no anti-cancer effects. They concluded that the cancer-fighting compound, closely associated with the pregnancy hormone, must be removed when hCG is purified.

Both clinical-grade and recombinant hCG are approved by the U.S. Food and Drug Administration as prescription medications for the treatment of select cases of female infertility and as hormone treatment for men.

The researchers narrowed their search to small molecular weight factors present in clinical-grade hCG that they called hCG-like inhibitory products, or HIP. To find the active molecule or part of a molecule, they used a biochemical approach involving systematically splitting the molecule (fractionation), repeatedly performing biological assays and chemical characterization.

Their results indicate that a small metabolite—the product of transformation of a larger molecule carried throughout blood and urine—into a potent bioactive metabolite that affects living tissue.

“We don’t know if it changes only when needed,” Antakly said. “Perhaps in cancer, it changes to fight the disease.”

This HIP metabolite, they discovered, rides “piggyback” on the larger hCG molecule, which chaperones it to target cells. When hCG is extensively purified, the metabolite loses its ride and disappears, Antakly stated.

However, when he and his colleagues exposed human Kaposi’s sarcoma cells in tissue cultures to hCG after purification from pregnant women’s urine, he said the active HIP metabolite “wiped out the cancer cells completely.”

Antakly said they do not yet know whether a synthetic replica of the HIP metabolite, which they are developing, is safe and effective to use at high doses in patients with cancer. However, in preliminary tests in cancer patients, they have shown that the “natural” HIP (purified from clinical-grade hCG) is safe and has anti-cancer activity.

William Raillant-Clark | AlphaGalileo
Further information:
http://www.umontreal.ca

Further reports about: Mystery anti-cancer cancer-fighting hormone metabolite pregnancy sarcoma synthetic tumors urine

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

 
Latest News

New switch decides between genome repair and death of cells

27.09.2016 | Life Sciences

Nanotechnology for energy materials: Electrodes like leaf veins

27.09.2016 | Physics and Astronomy

‘Missing link’ found in the development of bioelectronic medicines

27.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>