Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRSA rates varied dramatically across geographic areas

03.06.2014

Researchers studied LA, San Francisco, Chicago, New York and Raleigh-Durham

The rates of community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) varied dramatically among academic medical centers in California, New York, Illinois and North Carolina, suggesting there is not a uniform change in the "national epidemic" of the "superbug" that has generated extensive public health concern over the past decade, according to a new study.


Dr. Brad Spellberg, LA BioMed infectious disease specialist, says dramatic differences in the incidence and rate of change in the number of MRSA and MSSA infections indicate ongoing, fundamental changes in bacterial ecology.

Credit: LA BioMed

The study, published online ahead of print in the journal Clinical Infectious Diseases, surveyed hospital records of 4,171 cases of MRSA and MRSA-related infections between 2008 and 2011 in five medical centers located in Los Angeles, San Francisco, Chicago, New York City and Raleigh-Durham, NC.

The rates of MRSA acquired in the community declined 57% from 2008-2011 in the Los Angeles medical center. In contrast, CO-MRSA rates tripled at the New York medical center, while the rates remained stable in San Francisco, Chicago and Raleigh-Durham. At the same time, the rates for a MRSA-related infection, methicillin-susceptible S. aureus (MSSA), tended to change in the opposite direction from MRSA rates.

Since MRSA and MSSA rates moved in opposite directions, the authors concluded: "Enhanced infection control efforts are unlikely to account for such variation in community onset infection rates"

"These dramatic differences in the incidence and rate of change in the number of MRSA and MSSA infections indicate ongoing, fundamental changes in bacterial ecology, which need further study to protect public health," said Brad Spellberg, MD, a Los Angeles Biomedical Research Institute (LA BioMed) infectious disease specialist and senior author of the study. "Fully understanding MRSA, MSSA and other antibiotic-resistant infections is essential to finding new approaches to save the lives and protect the health of our patients here and around the world."

First recognized in the early 1960s, MRSA became a major public health concern in the late 1980s because it had become endemic in most U.S. hospitals. In the 1990s, a new wave of the antibiotic-resistant staph infections acquired in the community swept the nation. These were not caused by bacteria that had escaped from the hospital. They were MSSA strains with a novel resistance element. These MSSA strain types, especially the ones with a genetic background known as USA 300, were highly virulent. Driven by the emergence of USA300, the incidence of MRSA infections rose dramatically in the 2000s.

In the mid-1990s, Los Angeles and Chicago were among the first regions in the country to be affected by the emergence of MRSA acquired in the community. The "epidemic" of these community-acquired antibiotic-resistant infections only recently reached New York, leading researchers to conclude that the relatively stable incidence of CO-MRSA in Chicago and the decline in Los Angeles will begin to be seen in East Coast cities in the near future.

"This study also found that more than half the MRSA cases involved the most virulent form of the bacteria, bacterium with the USA300 genetic background. But the incidence varied from 35% at one hospital to 80% at another," said Dr. Spellberg. "All these differences in rates suggest that the epidemiology and other factors of antibiotic resistance vary greatly, requiring further study to fully understand antibiotic-resistant bacteria."

###

Dr. Spellberg is the author of the book, "Rising Plague," which examined the rise of antibiotic resistant infections and the failure to develop new antibiotics to combat them. The other researchers engaged in the study were: Arnold S. Bayer, Loren G. Miller and Raul Macias-Gil, LA BioMed; Michael Z. David, Robert S. Daum, Alison Baesa, Susan Boyle-Vavra and Julia Sieth, University of Chicago; Henry F. Chambers and Joann Volinski, University of California, San Francisco; Vance G. Fowler, Jr. and Thomas H. Rude, Duke University Medical Center, and Belinda Ostrowsky and Philip Gialanella, Montefiore Medical Center/Albert Einstein College of Medicine in New York.

About LA BioMed

Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and much more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit http://www.LABioMed.org

Laura Mecoy | Eurek Alert!

Further reports about: BioMed Biomedical MRSA MSSA Medical acquired antibiotic bacteria differences epidemic infections resistance virulent

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.

Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Paper – Panacea Green Infrastructure?

30.09.2016 | Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

 
Latest News

First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

30.09.2016 | Materials Sciences

New Technique for Finding Weakness in Earth’s Crust

30.09.2016 | Earth Sciences

Cells migrate collectively by intermittent bursts of activity

30.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>