Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Moffitt Cancer Center Researchers Study Effect of Chemotherapy Combined with Immunotherapy for Advanced Cancers

09.10.2012
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Tianjin Medical University Cancer Institute and Hospital in China have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect.
The results, achieved by testing cancer cells in a laboratory, are surprising because chemotherapy generally reduces immunity and could cancel out the benefits of immunotherapy when given together.

Their study appears in the Aug. 31 online issue of Cancer Research, a publication of the American Association for Cancer Research.
“Our question of interest for this study was ‘Can immunotherapy be used in combination with conventional chemotherapy in patients with advanced cancer?’ ” said study lead author Dmitry I. Gabrilovich, M.D., Ph.D., senior member of Moffitt’s Immunology Program. “The use of conventional cancer chemotherapy in combination with immunotherapy was previously not thought to be appropriate due to the immunosuppresive effects usually associated with chemotherapy. However, we identified a mechanism by which the two therapies could work together.”

The mechanism involved was the dramatic upregulation of the mannose-6-phosphate receptor (MPR) to the tumor cell surface. According to the researchers, normally more than 90 percent of total MPR is localized inside the cells, but after chemotherapy, large amounts of MPR localized on the cell membrane.

The researchers attributed this to autophagy.
“Autophagy is a reversible process than can contribute to both tumor cell death and survival,” explained Gabrilovich. “When this pathway is initiated, cellular material is sequestered by autophagosome. The mechanism of autophagosome formation depends on the type of chemotherapy used.”

According to the authors, the MPR upregulation effect was seen in every tumor model they tested and with all drugs they used. However, the effect of the combined treatment was seen only when chemotherapy was given within a specific window of time during which levels of MPR were observed on tumor cells. Much more about the mechanism needs to be clarified, researchers said.

“The relationship between autophagy and tumor immunity requires further investigation,” Gabrilovich said. “Our study represents a novel concept relating to the interaction between cytotoxic T cells and tumor cells undergoing autophagy. We are suggesting that this process could be exploited during chemotherapy or radiation therapy, as well as with other treatments that cause autophagy of cells, although treatments need to be carefully timed.”

The authors concluded that their data demonstrated that combining chemotherapy and immunotherapy for patients with advanced cancer has “a strong rationale.”
Moffitt research scientist Rupal Ramakrishnan, Ph.D., was a first author and major contributor to this study. The work was supported in part by a grant from Donald A. Adam Comprehensive Melanoma Research Center of Excellence, National Institutes of Health grant R01CA103921 and by the analytic microscopy and flow cytometry cores at Moffitt.

About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

Kim Polacek | EurekAlert!
Further information:
http://www.moffitt.org

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>