Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mild thyroid dysfunction in early pregnancy linked to serious complications

25.06.2012
Even moderate thyroid dysfunction during early pregnancy significantly increases the risk of serious complications, underscoring the need for universal screening in the first trimester, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

"These findings add to the now increasing evidence from previous studies that all pregnant women, irrespective of their risk for thyroid problems, probably should be screened for thyroid dysfunction within the first three months of getting pregnant," said study lead author Jubbin Jagan Jacob, M.D., associate professor at Christian Medical College and Hospital, Ludhiana in Punjab, India.

Thyroid hormone is produced by the thyroid gland, which is located in the neck, and helps regulate the process of turning food into energy. Excessively low hormone production, or hypothyroidism, may cause symptoms like fatigue, sensitivity to cold temperatures, constipation, and depression.

During pregnancy untreated, hypothyroidism is associated with an increased risk of miscarriage, stillbirth, low birth weight, and other serious complications. Although previous research has suggested that women with moderate thyroid dysfunction, or subclinical hypothyroidism, also are more likely to suffer complications, the level of risk was uncertain.

In this study, investigators found that even mild thyroid dysfunction that did not meet the criteria for hypothyroidism greatly increased the risk of serious problems. Compared to pregnant women with normal thyroid function, the risk was:

- doubled for miscarriage (¡Ü20 weeks of pregnancy), premature labor, and low birth weight

- seven times greater for still birth

Screening for hypothyroidism involves taking a thorough history of symptoms, as well as a simple blood test to measure levels of another hormone, called thyroid-stimulating-hormone, or TSH, that promotes thyroid-hormone production. At this time, only pregnant women with clinical symptoms of hypothyroidism are routinely tested. Once diagnosed, the condition can be effectively controlled with medication that replaces natural thyroid hormone with a synthetic version.

Investigators recruited 1,000 pregnant women in their first trimester of pregnancy for the study, as part of a larger project of routine thyroid screening during early pregnancy. They then measured the level of thyroid functioning using the TSA test.

Normal thyroid function was identified in 533 patients, and 263 had mild dysfunction. The remaining patients were diagnosed with hypothyroidism and withdrawn from the study for treatment. Follow-up continued until the completion of pregnancy.

Jacob and his team then compared rates of miscarriage, stillbirth, premature labor, and low birth weight. They also analyzed several other complications, as well, but these did not differ significantly between women with normal versus moderately low thyroid functioning.

"Our conclusions are that all pregnant women need to be screened for thyroid dysfunction at their first visit," Jacob said. "This should form the basis for the national societies to make a change in their guidelines." Christian Medical College and Hospital funded the study.

Aaron Lohr | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>