In recent years, researchers at Lund University, Sweden, have developed a technique that can identify in advance which patients belong to this risk group. Within the next two years the method will be tested in Swedish hospitals. In the future, the technique may also be used in hospitals in other countries.
This, together with other research within the Breast Cancer Initiative, as the project is called, has been awarded SEK 25 million from the Swedish innovation agency Vinnova. The project is part of the interdisciplinary cancer centre Create Health, where immunologists, tumour biologists, nanotechnologists, bioinformaticians and cancer researchers work together.
“This campaign means that our research can benefit patients earlier”, comments Carl Borrebaeck, Professor of Immunotechnology at Lund University and programme director for Create Health.
He and his colleagues aim to significantly shorten the waiting times for test results and information about continued treatment. The idea is to build a diagnostic clinic next to the operating theatre. The tumour can then be analysed while the patient is still on the operating table and the surgeon, oncologist and pathologist can together make a diagnosis and decide on the right treatment.
The research is based on a unique technique developed by the researchers in Lund. By analysing patterns of biomarkers, or protein molecules, in the blood, it is possible to obtain information about what type of cancer the patient has and what the prognosis is.
“We also map the tumour cells’ genome. Using this map, we can find out how responses to different types of treatment may relate to specific genes. This knowledge could be of great help in selecting the right treatment”, says Carl Borrebaeck.
The Create Health group is also in the process of developing a breast cancer index. Blood and tissue samples from patients with breast tumours are analysed on both protein and gene level and a unique ‘fingerprint’ of each tumour is obtained.
“Our aim is to analyse all the tumours in southern Sweden. This collection of samples also improves the collaboration between clinicians and researchers, as well as the chances to be able to quickly implement our research results in a clinical setting”, emphasises Carsten Rose, Professor of Oncology and head of division at Skåne University Hospital.
When it comes to the work on early identification of which patients are at risk of metastasis, the research has come a long way and has now entered its final stage.
“Currently, all women receive the same harsh treatment. However, with our technique it is possible to select which patients actually need it, and therefore also which only need a significantly milder treatment. The improved prognosis can reduce side-effects and unnecessary suffering for the patient, as well as saving a lot of money”, says Carsten Rose.
The Breast Cancer Initiative is part of Create Health, which comprises projects run by professors Åke Borg (oncology), Peter James (proteomics), Carl Borrebaeck (cancer immunology) and Carsten Rose (oncology).
For more information, please contact Carl Borrebaeck, Professor of Immunotechnology at Lund University, +46 46 222 96 13, +46 708 21 83 30, Carl.Borrebaeck@rektor.lu.se; Carsten Rose, Professor of Oncology and head of division at Skåne University Hospital, +46 46 17 69 20, +46 702 577509, Carsten.Rose@skane.se; Åke Borg, Professor of Oncology at Lund University, +46 46 177502, Ake.Borg@med.lu.se; Peter James, Professor of Proteomics at Lund University, +46 46 222 1496, +46 702 477960, Peter.James@immun.lth.se.
Megan Grindlay | idw
A whole-body approach to understanding chemosensory cells
13.12.2017 | Tokyo Institute of Technology
Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
13.12.2017 | Health and Medicine
13.12.2017 | Physics and Astronomy
13.12.2017 | Life Sciences