Affects men but not women
Treatment for opioid addiction tampers with the testosterone levels of male but not female opioid users, McMaster University research has shown.
In a paper published today by the journal Scientific Reports, the researchers say addiction treatment may need to change to address the side-effect.
The study found men using methadone, which is used for opioid addiction treatment, have significantly suppressed testosterone levels of about a quarter of the testosterone of men not using opioids. In women using methadone for addiction treatment, testosterone levels were not significantly impacted, even considering the menstrual cycle.
Low testosterone in men has been associated with poor quality of life as well as erectile dysfunction, fatigue, and mood disturbances.
"We expect that treating testosterone deficiency will improve outcomes of methadone treatment for patients, including treatment response and retention," said Dr. Zena Samaan, principal investigator of the study.
"Doctors should also ensure the patients are being prescribed the lowest dose of opioids including methadone for effective treatment to minimize testosterone suppression."
She added that this is a particular issue in Canada, the second largest consumer of opioids in the world.
Dr. Samaan is an associate professor of the psychiatry and behavioural neurosciences department of McMaster's Michael G. DeGroote School of Medicine.
The study involved information from 231 patients with opioid dependence receiving methadone in Ontario, as well as 783 Ontarians not using opioids. It was funded by the Drug Safety and Effectiveness Network of the Canadian Institutes of Health Research and the McMaster Department of Psychiatry and Behavioural Neurosciences. The study was conducted by the Population Genomics Program of McMaster's Chanchlani Research Centre, and Ontario Addiction Treatment Centres.
For more information:
Faculty of Health Sciences
905-525-9140, ext. 22169
Psychiatry and Behavioural Neurosciences
Veronica McGuire | Eurek Alert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering