Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lung microbes protect against asthma

15.05.2014

Whether or not people develop asthma may be determined in the first few weeks after birth according to a study of mice funded by the Swiss National Science Foundation (SNSF). The study suggests that microbes in the lungs stimulate the newborn's immune system.

Our lungs were long considered to be germfree and sterile. It was only recently discovered that, like our intestines and skin, our respiratory organs are colonised by bacteria. Now, tests conducted on mice by researchers working with Benjamin Marsland at the University Hospital in Lausanne have shown that these lung microbes offer protection against allergic asthma (*).

The researchers exposed the mice to an extract obtained from house dust mites. Neonates had a much stronger allergic reaction to the extract than older mice. Why? The lungs in newborn mice have not yet been colonised by the microbes that alter the immune system and make its responses less prone to allergic reactions.

Two-week adaptation process

... more about:
»allergens »humans »immune »lungs »microbes »microbial »newborn

The researchers have discovered that the process of colonisation and adaptation takes place during the first two weeks of the mouse's life. Young mice that were kept completely germ-free remained susceptible to asthma and had excessive immune responses to dust mite allergens even later in life.

Marsland and his team have already started studying whether lung microbes ensure healthy airways in humans as well. Pilot studies involving newborn babies in Switzerland and New Zealand indicate that the situation may be similar for men and mice. Further studies are required, however, to identify the potential mechanisms in humans.

Focus on newborns

"There would appear to be a developmental window early in life that determines whether or not an individual will develop asthma later," Marsland says. Until now, scientists and doctors have focused on asthma essentially from the point of view of the course of the disease and possible direct triggers. "We should probably focus on a much earlier stage, that of newborns."

What Marsland wants to know now is how big the developmental window is for building up the immune system in childhood. He hopes that the new discovery will help prevent asthma. Perhaps by encouraging pregnant women to eat more fruit and vegetables - quite recently Marsland showed that the dietary fibre contained in these foodstuffs also protects against allergic asthma by altering the microbial flora. That protection might be passed on to newborn babies.

(*) Eva Gollwitzer, Sejal Saglani, Aurélien Trompette, Koshika Yadava, Rebekah Sherburn, Kathy McCoy, Laurent Nicod, Clare Lloyd & Benjamin Marsland (2014). Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nature Medicine online. doi:10.1038/nm.3568
(journalists can obtain a pdf file from the SNSF by writing to: com@snf.ch)

Contact
Prof Benjamin J. Marsland
Pneumology Service
Lausanne University Hospital (CHUV)
CH-1011 Lausanne
Tel: +41 21 314 13 78
E-mail: benjamin.marsland@chuv.ch

Weitere Informationen:

http://www.snsf.ch/media

Media Abteilung Kommunikation | idw - Informationsdienst Wissenschaft

Further reports about: allergens humans immune lungs microbes microbial newborn

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>