Being able to better define which patients might experience a cancer recurrence is important, especially given the controversies surrounding the use of adjuvant therapies, particularly postoperative radiation therapy (RT), for patients with non-small cell lung cancer (NSCLC).
In 2009, the International Association for the Study of Lung Cancer (IASLC) published its 7th edition of the tumor, node, metastasis (TNM) classification, which was developed in collaboration with the American Joint Committee on Cancer and the Union Internationale Contre le Cancer. The changes were based on an analysis of a large international database.
Researchers at Duke University School of Medicine in Durham, N.C., analyzed 709 patients who had undergone surgery for non-small cell lung cancer between 1995 and 2005. Stage was assigned based on both TNM 6 and TNM 7. The 5-year actuarial risk of local/regional recurrence (LRR) for all patients was 23%. None of the patients received any adjuvant chemotherapy or radiation therapy.
When patients were converted from TNM 6 to TNM 7, about 13% were placed in a higher stage and 8% in a lower stage. For most malignancies, increasing stage is generally associated with a higher risk of disease recurrence.
Five-year rates of local/regional recurrence for stages IA, IB, IIA, IIB and IIIA disease using TNM 6 were 16%, 26%, 43%, 35% and 40%, respectively. Using TNM 7, the corresponding rates were 16%, 23%, 37%, 39% and 30%.
"The TNM 7 system seems to be a better predictor for LRR after surgery for NSCLC than TNM 6," researchers wrote in the study. "This information may prove to be valuable when designing future studies of postoperative RT."
About the Journal of Thoracic Oncology:
The Journal of Thoracic Oncology (JTO) is the official monthly journal of the International Association for the Study of Lung Cancer (IASLC). It is a prized resource for medical specialists and scientists who focus on the detection, prevention, diagnosis and treatment of lung cancer. It emphasizes a multidisciplinary approach, including original research (clinical trials and translational or basic research), reviews and opinion pieces. To learn more about the JTO please visit http://journals.lww.com/jto/pages/default.aspx.
The Denver-based International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1972, the association's membership includes more than 3,000 lung cancer specialists in 80 countries.
IASLC members work toward developing and promoting the study of etiology, epidemiology, prevention, diagnosis, treatment and all other aspects of lung cancer and thoracic malignancies. IASLC members work to enhance the understanding of lung cancer among scientists, members of the medical community and the public. To learn more about the IASLC please visit http://iaslc.org/
Renée McGaw | EurekAlert!
Chronic stress induces fatal organ dysfunctions via a new neural circuit
21.08.2017 | Hokkaido University
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
21.08.2017 | Materials Sciences
21.08.2017 | Health and Medicine
21.08.2017 | Materials Sciences