Men who at the age of 18 years have poorer cardiovascular fitness and/or a lower IQ more often suffer from dementia before the age of 60. This is shown in a recent study encompassing more than one million Swedish men.
In several extensive studies, researchers at the Sahlgrenska Academy of The University of Gothenburg have previously analyzed Swedish men's conscription results and were able to show a correlation between cardiovascular fitness as a teenager and health problems in later life.
Jenny Nyberg, Ph.D. and Researcher at Sahlgrenska Academy, Gothenburg University
The University of Gothenburg
Increased risk for early-onset dementia
In their latest study, based on data from 1.1 million young Swedish men, the Gothenburg researcher team shows that those with poorer cardiovascular fitness and/or lower IQ in their teenage years more often suffer from early-onset dementia.
"Previous studies have shown the correlation between cardiovascular fitness and the risk of dementia in old age. Now, for the first time, we can show that the increased risk also applies to early-onset dementia and its precursors," says Sahlgrenska Academy researcher Jenny Nyberg, who headed the study.
Controlled for other risk factors
Expressed in figures, the study shows that men who when conscripted had poorer cardiovascular fitness were 2.5 times more likely to develop early-onset dementia later in life. A lower IQ entailed a 4 times greater risk, and a combination of both poor cardiovascular fitness and low IQ entailed a 7 times greater risk of early-onset dementia.
The increased risk remained even when controlled for other risk factors, such as heredity, medical history, and social-economic circumstances.
Fitness strengthens the brain
"We already knew that physical and cognitive exercise reduces the risk of neurological disease. Physical exercise increases nerve cell complexity and function and even generation of new nerve cells in the adult brain, which strengthens our mental and physiological functions. In other words, good cardiovascular fitness makes the brain more resistant to damage and disease," says Prof. Georg Kuhn, senior author of the study.
People who develop early-onset dementia are often of working age and can have children still living at home, which means the consequences for both the sufferers and their families are even more serious. Despite this, patients with early-onset dementia are a relatively overlooked group.
"This makes it important to initiate more research into how physical and mental exercise can affect the prevalence of different types of dementia. Perhaps exercise can be used as both a prophylactic and a treatment for those in the risk zone for early-onset dementia," says Nyberg.
The article Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia was published online in the scientific journal Brain on 7 March.
Link to article: http://brain.oxfordjournals.org/content/early/2014/03/06/brain.awu041.abstract
FACTS ABOUT DEMENTIA AND THE QUOTED STUDY
Dementia is not a disease but a group of different diseases characterized by the gradual worsening of cognitive abilities. Dementia is seen across all ethnic groups and increasingly so with advancing age. Among 65–69-year-olds, about 2 percent are afflicted, with this figure doubling for every five years of age.
The quoted study encompassed all Swedish men conscripted for mandatory military service between the years 1968 and 2005, a total of 1.1 million individuals. In the study, the researchers have compared the results from the conscripts' cardiovascular fitness and IQ tests with information from national disease registries. During the study period, a total of 660 men were diagnosed with early-onset dementia.
Jenny Nyberg, Ph.D. and Researcher at Sahlgrenska Academy, The University of Gothenburg, firstname.lastname@example.org
Georg Kuhn, Professor and Researcher at Sahlgrenska Academy, The University of Gothenburg, email@example.com
Krister Svahn | idw - Informationsdienst Wissenschaft
New evidence: How amino acid cysteine combats Huntington's disease
27.07.2016 | Johns Hopkins Medicine
Cord blood outperforms matched, unrelated donor in bone marrow transplant
27.07.2016 | University of Colorado Anschutz Medical Campus
Transparent electronics devices are present in today’s thin film displays, solar cells, and touchscreens. The future will bring flexible versions of such devices. Their production requires printable materials that are transparent and remain highly conductive even when deformed. Researchers at INM – Leibniz Institute for New Materials have combined a new self-assembling nano ink with an imprint process to create flexible conductive grids with a resolution below one micrometer.
To print the grids, an ink of gold nanowires is applied to a substrate. A structured stamp is pressed on the substrate and forces the ink into a pattern. “The...
A new Fraunhofer MEVIS method conveys medical interrelationships quickly and intuitively with innovative visualization technology
On the monitor, a brain spins slowly and can be examined from every angle. Suddenly, some sections start glowing, first on the side and then the entire back of...
Researchers at the U.S. Department of Energy's (DOE) Ames Laboratory have discovered an unusual property of purple bronze that may point to new ways to achieve high temperature superconductivity.
While studying purple bronze, a molybdenum oxide, researchers discovered an unconventional charge density wave on its surface.
Munich Physicists have developed a novel electron microscope that can visualize electromagnetic fields oscillating at frequencies of billions of cycles per second.
Temporally varying electromagnetic fields are the driving force behind the whole of electronics. Their polarities can change at mind-bogglingly fast rates, and...
Breakup of continents with two speed: Continents initially stretch very slowly along the future splitting zone, but then move apart very quickly before the onset of rupture. The final speed can be up to 20 times faster than in the first, slow extension phase.phases
Present-day continents were shaped hundreds of millions of years ago as the supercontinent Pangaea broke apart. Derived from Pangaea’s main fragments Gondwana...
15.07.2016 | Event News
15.07.2016 | Event News
11.07.2016 | Event News
28.07.2016 | Information Technology
28.07.2016 | Materials Sciences
28.07.2016 | Earth Sciences